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Isomerizations of N-(α-aminoalkyl)-1,2,4-triazoles and N-(α-aminoalkyl)tetrazoles
Journal article   Peer reviewed

Isomerizations of N-(α-aminoalkyl)-1,2,4-triazoles and N-(α-aminoalkyl)tetrazoles

Alan R. Katritzky, Andrzej Jóźwiak, Ping Lue, Konstantina Yannakopoulou, Gus J. Palenik and Zhang Ze-Ying
Tetrahedron, Vol.46(2), pp.633-640
1990

Abstract

The title compounds exist as equilibrium mixtures of the N-1 and N-2 isomers in solution. However, the crystal structure of 3-(1-hydroxycyclohexyl)-1-(α-pyrrolidinomethyl)-1,2,4-triazole discloses only this isomer in the solid state. Evidence for the nature of the isomerization processes in solution is provided. The kinetic and thermodynamic parameters are measured and qualitatively assessed.

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