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Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG
Journal article   Peer reviewed

Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

Gyoergy Szekely, Marc Schaepertoens, Piers R. J. Gaffney and Andrew G. Livingston
Polymer chemistry, Vol.5(3), pp.694-697
07/02/2014
DOI: https://doi.org/10.1039/c3py01367g

Abstract

Physical Sciences Polymer Science Science & Technology
Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG(8)) building block to give MeO-EG(24)-OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.

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