Abstract
A simple and efficient one-pot approach for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles directly from corresponding aldehydes and amidoximes using recyclable KF-Al2O3 catalyst system under solvent free conditions have been developed. The 'domino' one-pot three component approach involves hydroxyamination of benzonitrile to amidoxim followed by 1,3-dipolar cycloaddition with aldehyde to generate 3,5-disubstituted-1,2,4-oxadiazoles. The method is operationally simple, regioselective, economical, and possesses excellent functional group compatibility to produce structurally assorted 1,2,4-oxadiazoles in good yields.