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Kinetic resolution of amines by acylation using 3-diacylaminoquinazolin-4(3H)-ones
Journal article

Kinetic resolution of amines by acylation using 3-diacylaminoquinazolin-4(3H)-ones

Abdullah G Al-Sehemi, Robert S Atkinson, John Fawcett and David R Russell
Chemical Communications, (1), pp.43-44
2000

Abstract

Four diastereoisomeric 3-diacylaminoquinazolinones 8a-d have been separated and identified by X-ray structure determinations on three of them: their stoichiometric reactions with α-phenylethylamine and with 2-methylpiperidine (2 equiv. of amine) gave the corresponding N -(2-acetoxypropanoyl)amine and unreacted amine in high diastereomeric/enantiomeric excess.

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