Abstract
Three Zingiberofficinale rout extracts namely; chloroform, ethanol and aqueous were investigated for its ability to inhibit crystallization of calcium oxalate monohydrate crystals (COM) which is the major constituents of kidney stones. The results obtained showed that the different extracts of Zingiberofficinale act as inhibitors of calcium oxalate stones crystallization. The effect of aqueous extract of Zingiberofficinale on the rate of crystallization of calcium oxalate crystals was higher than the ethanol extract followed by chloroform extract. In conclusion, these results have proved the folk medicine use of Zingiberofficinale for kidney stones and the extracts of it may be beneficial for the treatment of nephrolithiasis but a detailed preclinical and clinical study is required