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L-proline catalyzed selective synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles
Journal article   Peer reviewed

L-proline catalyzed selective synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles

Ravi Varala, Aayesha Nasreen, Ramu Enugala and Srinivas R. Adapa
Tetrahedron letters, Vol.48(1), pp.69-72
01/01/2007
DOI: https://doi.org/10.1016/j.tetlet.2006.11.010

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
L-Proline (10 mol %) was found to be a versatile organocatalyst for the selective synthesis of 2-aryl-1-arylmethyl-1-H-benzimidazoles from a wide range of substituted o-phenylenediamines and aldehydes in moderate to excellent isolated yields (32-95%) under mild conditions using chloroform as a solvent at ambient temperature. (c) 2006 Elsevier Ltd. All rights reserved.

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