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Labeling of nucleosides with fluorescent 6-chloro-2,3-napthalimide
Journal article   Peer reviewed

Labeling of nucleosides with fluorescent 6-chloro-2,3-napthalimide

A. R. Katritzky, S. Ozcan and E. Todadze
Bioorganic & medicinal chemistry letters, Vol.20(17), pp.5326-5328
01/09/2010
DOI: https://doi.org/10.1016/j.bmcl.2010.06.100
PMID: 20673628

Abstract

Chemistry Chemistry, Medicinal Chemistry, Organic Life Sciences & Biomedicine Pharmacology & Pharmacy Physical Sciences Science & Technology
The synthesis and fluorescence properties of new highly fluorescent nucleosides are reported. 6-Chloro-2,3-napthalimides activated with benzotriazole and chlorine label nucleosides quickly and efficiently in yields of 70-82%: the products exhibit quantum efficiencies of 10-94% in solvents of diverse polarity. (C) 2010 Elsevier Ltd. All rights reserved.

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