Abstract
The marine-derived fungus
isolated from the Mediterranean sponge
and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (
-
), seven (3
)-resorcylide derivatives (
-
), two butenolide-resorcylide dimers (
and
), and three dihydroisocoumarins (
-
). Among them, fourteen compounds (
-
,
-
) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B (
and
) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC
values of 3.9 and 1.3 µM, respectively.