Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Robert A. Scott; Vasiliki Lagou; Ryan P. Welch; Eleanor Wheeler; May E. Montasser; Jian'An Luan; Reedik Maegi; Rona J. Strawbridge; Emil Rehnberg; Stefan Gustafsson; Stavroula Kanoni; Laura J. Rasmussen-Torvik; Loïc Yengo; Cécile Lecoeur; Dmitry Shungin; Serena Sanna; Carlo Sidore; Paul C. D. Johnson; J. Wouter Jukema; Toby Johnson; Anubha Mahajan; Niek Verweij; Gudmar Thorleifsson; Jouke-Jan Hottenga; Sonia Shah; Albert V. Smith; Bengt Sennblad; Christian Gieger; Perttu Salo; Markus Perola; Nicholas J. Timpson; David M. Evans; Beate St Pourcain; Ying Wu; Jeanette S. Andrews; Jennie Hui; Lawrence F. Bielak; Wei Zhao; Momoko Horikoshi; Pau Navarro; Aaron Isaacs; Jeffrey R. O'Connell; Kathleen Stirrups; Veronique Vitart; Caroline Hayward; Tonu Esko; Evelin Mihailov; Ross M. Fraser; Tove Fall; Benjamin F. Voight; Soumya Raychaudhuri; Han Chen; Cecilia M. Lindgren; Andrew P. Morris; Nigel W. Rayner; Neil Robertson; Denis Rybin; Ching-Ti Liu; Jacques S. Beckmann; Sara M. Willems; Peter S. Chines; Anne U. Jackson; Hyun Min Kang; Heather M. Stringham; Kijoung Song; Toshiko Tanaka; John F. Peden; Anuj Goel; Andrew A. Hicks; Ping An; Martina Mueller-Nurasyid; Anders Franco-Cereceda; Lasse Folkersen; Letizia Marullo; Hanneke Jansen; Albertine J. Oldehinkel; Marcel Bruinenberg; James S. Pankow; Kari E. North; Nita G. Forouhi; Ruth J. F. Loos; Sarah Edkins; Tibor V. Varga; Goeran Hallmans; Heikki Oksa; Mulas Antonella; Ramaiah Nagaraja; Stella Trompet; Ian Ford; Stephan J. L. Bakker; Augustine Kong; Meena Kumari; Bruna Gigante; Christian Herder; Patricia B. Munroe; Mark Caulfield; Jula Antti; Massimo Mangino; Kerrin Small; Serge Hercberg; DIAbet Genetics Replication; Panos Deloukas

doi:10.1038/ng.2385

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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Journal article

Peer reviewed

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Robert A. Scott, Vasiliki Lagou, Ryan P. Welch, Eleanor Wheeler, May E. Montasser, Jian'An Luan, Reedik Maegi, Rona J. Strawbridge, Emil Rehnberg, Stefan Gustafsson, …

Nature genetics, Vol.44(9), pp.991-+

01/09/2012

DOI: https://doi.org/10.1038/ng.2385

PMCID: PMC3433394

PMID: 22885924

Abstract

Life Sciences

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.

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Title: Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Creators - without role: Robert A. Scott - Addenbrooke's Hospital
Vasiliki Lagou - Wellcome Trust
Ryan P. Welch - Michigan State University
Eleanor Wheeler - Wellcome Sanger Institute
May E. Montasser - University of Maryland [College Park]
Jian'An Luan - Addenbrooke's Hospital
Reedik Maegi - Wellcome Trust
Rona J. Strawbridge - Karolinska Institutet
Emil Rehnberg - Karolinska Institutet
Stefan Gustafsson - Karolinska Institutet
Stavroula Kanoni - Wellcome Sanger Institute
Laura J. Rasmussen-Torvik - Northwestern University [Evanston]
Loïc Yengo - Université Lille Nord de France (COMUE)
Cécile Lecoeur - Université Lille Nord de France (COMUE)
Dmitry Shungin - Lund University
Serena Sanna - Consiglio Nazionale delle Ricerche
Carlo Sidore - Michigan State University
Paul C. D. Johnson - University of Glasgow
J. Wouter Jukema - Netherlands Heart Institute
Toby Johnson - Queen Mary University of London
Anubha Mahajan - Wellcome Trust
Niek Verweij - University of Groningen
Gudmar Thorleifsson - deCODE Genetics
Jouke-Jan Hottenga - Vrije Universiteit Amsterdam
Sonia Shah - University College of London [London]
Albert V. Smith - Icelandic Heart Association
Bengt Sennblad - Karolinska Institutet
Christian Gieger - German Research Center for Environmental Health - Helmholtz Center München (GmbH)
Perttu Salo - Natl Inst Hlth & Welf
Markus Perola - University of Tartu
Nicholas J. Timpson - University of Bristol
David M. Evans - University of Bristol
Beate St Pourcain
Ying Wu - North Carolina State University
Jeanette S. Andrews - Wake Forest School of Medicine
Jennie Hui - Sir Charles Gairdner Hospital
Lawrence F. Bielak - Michigan State University
Wei Zhao - Michigan State University
Momoko Horikoshi - Wellcome Trust
Pau Navarro - University of Edinburgh
Aaron Isaacs - Centre for Medical Systems Biology
Jeffrey R. O'Connell - University of Maryland [College Park]
Kathleen Stirrups - Wellcome Sanger Institute
Veronique Vitart - University of Edinburgh
Caroline Hayward - University of Edinburgh
Tonu Esko - University of Tartu
Evelin Mihailov - University of Tartu
Ross M. Fraser - University of Edinburgh
Tove Fall - Karolinska Institutet
Benjamin F. Voight - Broad Institute
Soumya Raychaudhuri - Brigham and Women's Hospital
Han Chen - Boston University
Cecilia M. Lindgren - Wellcome Trust
Andrew P. Morris - Wellcome Trust
Nigel W. Rayner - Wellcome Trust
Neil Robertson - Wellcome Trust
Denis Rybin - Boston University
Ching-Ti Liu - Boston University
Jacques S. Beckmann - College Station Medical Center
Sara M. Willems - Erasmus University Rotterdam
Peter S. Chines - National Human Genome Research Institute
Anne U. Jackson - Michigan State University
Hyun Min Kang - Michigan State University
Heather M. Stringham - Michigan State University
Kijoung Song - GlaxoSmithKline
Toshiko Tanaka - National Institute on Aging
John F. Peden
Anuj Goel
Andrew A. Hicks
Ping An
Martina Mueller-Nurasyid
Anders Franco-Cereceda
Lasse Folkersen
Letizia Marullo
Hanneke Jansen
Albertine J. Oldehinkel
Marcel Bruinenberg
James S. Pankow
Kari E. North
Nita G. Forouhi
Ruth J. F. Loos
Sarah Edkins
Tibor V. Varga
Goeran Hallmans
Heikki Oksa
Mulas Antonella
Ramaiah Nagaraja
Stella Trompet
Ian Ford
Stephan J. L. Bakker
Augustine Kong
Meena Kumari
Bruna Gigante
Christian Herder
Patricia B. Munroe
Mark Caulfield
Jula Antti
Massimo Mangino
Kerrin Small
Serge Hercberg - Unité de Recherche en Epidémiologie Nutritionnelle
DIAbet Genetics Replication
Panos Deloukas - King Abdulaziz University
Publication Details: Nature genetics, Vol.44(9), pp.991-+
Publisher: Nature Publishing Group
Identifiers: 9936933508331
Academic Unit: King Abdulaziz University; King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article