Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert; Inke R. Koenig; Sekar Kathiresan; Muredach P. Reilly; Themistocles L. Assimes; Hilma Holm; Michael Preuss; Alexandre F. R. Stewart; Maja Barbalic; Christian Gieger; Devin Absher; Zouhair Aherrahrou; Hooman Allayee; David Altshuler; Sonia S. Anand; Karl Andersen; Jeffrey L. Anderson; Diego Ardissino; Stephen G. Ball; Anthony J. Balmforth; Timothy A. Barnes; Diane M. Becker; Lewis C. Becker; Klaus Berger; Joshua C. Bis; S. Matthijs Boekholdt; Eric Boerwinkle; Peter S. Braund; Morris J. Brown; Mary Susan Burnett; Ian Buysschaert; John F. Carlquist; Li Chen; Sven Cichon; Veryan Codd; Robert W. Davies; George Dedoussis; Abbas Dehghan; Serkalem Demissie; Joseph M. Devaney; Patrick Diemert; Ron Do; Angela Doering; Sandra Eifert; Nour Eddine El Mokhtari; Stephen G. Ellis; Roberto Elosua; James C. Engert; Stephen E. Epstein; Ulf de Faire; Marcus Fischer; Aaron R. Folsom; Jennifer Freyer; Bruna Gigante; Domenico Girelli; Solveig Gretarsdottir; Vilmundur Gudnason; Jeffrey R. Gulcher; Eran Halperin; Naomi Hammond; Stanley L. Hazen; Albert Hofman; Benjamin D. Horne; Thomas Illig; Carlos Iribarren; Gregory T. Jones; J. Wouter Jukema; Michael A. Kaiser; Lee M. Kaplan; John J. P. Kastelein; Kay-Tee Khaw; Joshua W. Knowles; Genovefa Kolovou; Augustine Kong; Reijo Laaksonen; Diether Lambrechts; Karin Leander; Guillaume Lettre; Mingyao Li; Wolfgang Lieb; Christina Loley; Andrew J. Lotery; Pier M. Mannucci; Seraya Maouche; Nicola Martinelli; Pascal P. McKeown; Christa Meisinger; Thomas Meitinger; Olle Melander; Pier Angelica Merlini; Vincent Mooser; Thomas Morgan; Thomas W. Muehleisen; Joseph B. Muhlestein; Thomas Muenzel; Kiran Musunuru; Janja nahrstaedt; Christopher P. Nelson; Markus M. Noethen; Oliviero Olivieri; Riyaz S. Patel; Chris C. Patterson; Annette Peters; Flora Peyvandi; Liming Qu; Arshed A. Quyyumi; Daniel J. Rader; Loukianos S. Rallidis; Catherine Rice; Frits R. Rosendaal; Diana Rubin; Veikko Salomaa; M. Lourdes Sampietro; Manj S. Sandhu; Eric Schadt; Arne Schaefer; Arne Schillert; Stefan Schreiber; Juergen Schrezenmeir; Stephen M. Schwartz; David S. Siscovick; Mohan Sivananthan; Suthesh Sivapalaratnam; Albert Smith; Tamara B. Smith; Jaapjan D. Snoep; Nicole Soranzo; John A. Spertus; Klaus Stark; Kathy Stirrups; Monika Stoll; W. H. Wilson Tang; Stephanie Tennstedt; Gudmundur Thorgeirsson; Gudmar Thorleifsson; Maciej Tomaszewski; Andre G. Uitterlinden; Andre M. van Rij; Benjamin F. Voight; Nick J. Wareham; George A. Wells; H-Erich Wichmann; Philipp S. Wild; Christina Willenborg; Jaqueline C. M. Witteman; Benjamin J. Wright; Shu Ye; Tanja Zeller; Andreas Ziegler; Francois Cambien; Alison H. Goodall; L. Adrienne Cupples; Thomas Quertermous; Winfried Maerz; Christian Hengstenberg; Stefan Blankenberg; Willem H. Ouwehand; Alistair S. Hall; Panos Deloukas; John R. Thompson; Kari Stefansson; Robert Roberts; Unnur Thorsteinsdottir; Christopher J. O'Donnell; Ruth McPherson; Jeanette Erdmann; Nilesh J. Samani; CARDIoGRAM Consortium

doi:10.1038/ng.784

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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Journal article

Peer reviewed

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert, Inke R. Koenig, Sekar Kathiresan, Muredach P. Reilly, Themistocles L. Assimes, Hilma Holm, Michael Preuss, Alexandre F. R. Stewart, Maja Barbalic, Christian Gieger, …

Nature genetics, Vol.43(4), pp.333-U153

01/04/2011

DOI: https://doi.org/10.1038/ng.784

PMID: 21673312

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

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Title: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Creators - without role: Heribert Schunkert - University of Lübeck
Inke R. Koenig - University of Lübeck
Sekar Kathiresan - Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
Muredach P. Reilly - Univ Penn, Cardiovasc Inst, Philadelphia, PA 19104 USA
Themistocles L. Assimes - Stanford University
Hilma Holm - DeCODE Genet, Reykjavik, Iceland
Michael Preuss - University of Lübeck
Alexandre F. R. Stewart - University of Ottawa
Maja Barbalic - Univ Texas Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA
Christian Gieger - Helmholtz Zentrum München
Devin Absher - Association of Local Public Health Agencies
Zouhair Aherrahrou - University of Lübeck
Hooman Allayee - College Station Medical Center
David Altshuler - Broad Institute
Sonia S. Anand - McMaster University
Karl Andersen - College Station Medical Center
Jeffrey L. Anderson - University of Utah
Diego Ardissino - University of Parma
Stephen G. Ball - University of Leeds
Anthony J. Balmforth - University of Leeds
Timothy A. Barnes - University of Leicester
Diane M. Becker - Johns Hopkins University
Lewis C. Becker - Johns Hopkins University
Klaus Berger - University of Münster
Joshua C. Bis - University of Washington
S. Matthijs Boekholdt - University of Amsterdam
Eric Boerwinkle - Univ Texas Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA
Peter S. Braund - University of Leicester
Morris J. Brown - University of Cambridge
Mary Susan Burnett - Washington Hosp Ctr, Cardiovasc Res Inst, Medstar Hlth Res Inst, Washington, DC 20010 USA
Ian Buysschaert - Univ Hosp Gasthuisberg, Dept Cardiol, B-3000 Louvain, Belgium
John F. Carlquist - University of Utah
Li Chen - University of Ottawa
Sven Cichon - University of Bonn
Veryan Codd - University of Leicester
Robert W. Davies
George Dedoussis - Harokopio University of Athens
Abbas Dehghan - Erasmus MC
Serkalem Demissie - Boston University
Joseph M. Devaney - Washington Hosp Ctr, Cardiovasc Res Inst, Medstar Hlth Res Inst, Washington, DC 20010 USA
Patrick Diemert - University of Lübeck
Ron Do - McGill University
Angela Doering - Helmholtz Zentrum München
Sandra Eifert - Univ Munich, Klinikum Grosshadern, D-8000 Munich, Germany
Nour Eddine El Mokhtari - College Station Medical Center
Stephen G. Ellis - College Station Medical Center
Roberto Elosua - College Station Medical Center
James C. Engert - McGill University
Stephen E. Epstein - Washington Hosp Ctr, Cardiovasc Res Inst, Medstar Hlth Res Inst, Washington, DC 20010 USA
Ulf de Faire - Karolinska Institutet
Marcus Fischer - College Station Medical Center
Aaron R. Folsom - University of Minnesota
Jennifer Freyer - University of Lübeck
Bruna Gigante - Karolinska Institutet
Domenico Girelli - University of Verona
Solveig Gretarsdottir - DeCODE Genet, Reykjavik, Iceland
Vilmundur Gudnason - University of Iceland
Jeffrey R. Gulcher - DeCODE Genet, Reykjavik, Iceland
Eran Halperin - Tel Aviv University
Naomi Hammond - Wellcome Sanger Institute
Stanley L. Hazen - Cleveland Clin, Lerner Res Inst, Cleveland, OH 44106 USA
Albert Hofman - Erasmus MC
Benjamin D. Horne - University of Utah
Thomas Illig - Helmholtz Zentrum München
Carlos Iribarren - Kaiser Permanente
Gregory T. Jones - University of Otago
J. Wouter Jukema - Leiden University
Michael A. Kaiser - University of Leicester
Lee M. Kaplan
John J. P. Kastelein - University of Amsterdam
Kay-Tee Khaw - University of Cambridge
Joshua W. Knowles - Stanford University
Genovefa Kolovou - Onassis Cardiac Surg Ctr, Cardiol Dept 1, Athens, Greece
Augustine Kong - DeCODE Genet, Reykjavik, Iceland
Reijo Laaksonen - Tampere University
Diether Lambrechts - KU Leuven
Karin Leander - Karolinska Institutet
Guillaume Lettre - Montreal Heart Institute
Mingyao Li
Wolfgang Lieb - University of Lübeck
Christina Loley - University of Lübeck
Andrew J. Lotery - University of Southampton
Pier M. Mannucci - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Seraya Maouche - University of Lübeck
Nicola Martinelli - University of Verona
Pascal P. McKeown - Queens University
Christa Meisinger - Helmholtz Zentrum München
Thomas Meitinger - Helmholtz Zentrum München
Olle Melander - Lund University
Pier Angelica Merlini - Azienda Osped Niguarda CaGranda, Div Cardiol, Milan, Italy
Vincent Mooser - GlaxoSmithKline
Thomas Morgan - Vanderbilt University
Thomas W. Muehleisen - University of Bonn
Joseph B. Muhlestein - University of Utah
Thomas Muenzel - Johannes Gutenberg Univ Mainz, Med Klin & Poliklin, Univ Med Mainz, Mainz, Germany
Kiran Musunuru - Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
Janja nahrstaedt - University of Lübeck
Christopher P. Nelson - University of Leeds
Markus M. Noethen - University of Bonn
Oliviero Olivieri - University of Verona
Riyaz S. Patel - Emory University
Chris C. Patterson - Queens University
Annette Peters - Helmholtz Zentrum München
Flora Peyvandi - University of Milan
Liming Qu
Arshed A. Quyyumi - Emory University
Daniel J. Rader - Univ Penn, Cardiovasc Inst, Philadelphia, PA 19104 USA
Loukianos S. Rallidis - National and Kapodistrian University of Athens
Catherine Rice - Wellcome Sanger Institute
Frits R. Rosendaal - Leiden University
Diana Rubin - College Station Medical Center
Veikko Salomaa - Natl Inst Hlth & Welf, Chron Dis Epidemiol & Prevent Unit, Dept Chron Dis Prevent, Helsinki, Finland
M. Lourdes Sampietro - Leiden University
Manj S. Sandhu - Wellcome Sanger Institute
Eric Schadt - Menlo School
Arne Schaefer - Univ Kiel, Inst Klin Mol Biol, Kiel, Germany
Arne Schillert - University of Lübeck
Stefan Schreiber - Univ Kiel, Inst Klin Mol Biol, Kiel, Germany
Juergen Schrezenmeir - Max
Stephen M. Schwartz - University of Washington
David S. Siscovick - University of Washington
Mohan Sivananthan - Leeds Teaching Hosp Natl Hlth Serv Trust, Cardiol Div, Leeds, W Yorkshire, England
Suthesh Sivapalaratnam - University of Amsterdam
Albert Smith - University of Iceland
Tamara B. Smith - NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, NIH, Bethesda, MD 20892 USA
Jaapjan D. Snoep - Leiden University
Nicole Soranzo - Wellcome Sanger Institute
John A. Spertus - University of Missouri–Kansas City
Klaus Stark - College Station Medical Center
Kathy Stirrups - Wellcome Sanger Institute
Monika Stoll - University of Münster
W. H. Wilson Tang - College Station Medical Center
Stephanie Tennstedt - University of Lübeck
Gudmundur Thorgeirsson - College Station Medical Center
Gudmar Thorleifsson - DeCODE Genet, Reykjavik, Iceland
Maciej Tomaszewski - University of Leicester
Andre G. Uitterlinden - Erasmus MC
Andre M. van Rij - University of Otago
Benjamin F. Voight - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Nick J. Wareham - Massachusetts Rehabilitation Commission
George A. Wells
H-Erich Wichmann - Helmholtz Zentrum München
Philipp S. Wild - Johannes Gutenberg Univ Mainz, Med Klin & Poliklin, Univ Med Mainz, Mainz, Germany
Christina Willenborg - University of Lübeck
Jaqueline C. M. Witteman - Erasmus MC
Benjamin J. Wright - University of Leicester
Shu Ye - Queen Mary University of London
Tanja Zeller - Johannes Gutenberg Univ Mainz, Med Klin & Poliklin, Univ Med Mainz, Mainz, Germany
Andreas Ziegler - University of Lübeck
Francois Cambien - Université Paris Cité
Alison H. Goodall - University of Leicester
L. Adrienne Cupples - Boston University
Thomas Quertermous - Stanford University
Winfried Maerz - Synlab
Christian Hengstenberg - College Station Medical Center
Stefan Blankenberg - Johannes Gutenberg University Mainz
Willem H. Ouwehand - Wellcome Sanger Institute
Alistair S. Hall - University of Leeds
Panos Deloukas - Wellcome Sanger Institute
John R. Thompson - University of Leicester
Kari Stefansson - DeCODE Genet, Reykjavik, Iceland
Robert Roberts - University of Ottawa
Unnur Thorsteinsdottir - DeCODE Genet, Reykjavik, Iceland
Christopher J. O'Donnell - Framingham Heart Study
Ruth McPherson - University of Ottawa
Jeanette Erdmann - University of Lübeck
Nilesh J. Samani - University of Leicester
CARDIoGRAM Consortium
Publication Details: Nature genetics, Vol.43(4), pp.333-U153
Publisher: Springer Nature
Number of pages: 8
Grant note: G0801566; G1000143; MC_U106179471; G0401527 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission R01HL089650-02; HL087647 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K23 HL097151; K23 HL097151-02 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) ES/G007438/1 / Economic and Social Research Council; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) NF-SI-0507-10094 / National Institute for Health Research; National Institute for Health Research (NIHR) RG/09/012/28096; PG/08/094/26019 / British Heart Foundation
Identifiers: 9936908908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article