Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P. Morris; Benjamin F. Voight; Tanya M. Teslovich; Teresa Ferreira; Ayellet V. Segre; Valgerdur Steinthorsdottir; Rona J. Strawbridge; Hassan Khan; Harald Grallert; Anubha Mahajan; Inga Prokopenko; Hyun Min Kang; Christian Dina; Tonu Esko; Ross M. Fraser; Stavroula Kanoni; Ashish Kumar; Vasiliki Lagou; Claudia Langenberg; Jian'an Luan; Cecilia M. Lindgren; Martina Mueller-Nurasyid; Sonali Pechlivanis; N. William Rayner; Laura J. Scott; Steven Wiltshire; Loic Yengo; Leena Kinnunen; Elizabeth J. Rossin; Soumya Raychaudhuri; Andrew D. Johnson; Antigone S. Dimas; Ruth J. F. Loos; Sailaja Vedantam; Han Chen; Jose C. Florez; Caroline Fox; Ching-Ti Liu; Denis Rybin; David J. Couper; Wen Hong L. Kao; Man Li; Marilyn C. Cornelis; Peter Kraft; Qi Sun; Rob M. van Dam; Heather M. Stringham; Peter S. Chines; Krista Fischer; Pierre Fontanillas; Oddgeir L. Holmen; Sarah E. Hunt; Anne U. Jackson; Augustine Kong; Robert Lawrence; Julia Meyer; John R. B. Perry; Carl G. P. Platou; Simon Potter; Emil Rehnberg; Neil Robertson; Suthesh Sivapalaratnam; Alena Stancakova; Kathleen Stirrups; Gudmar Thorleifsson; Emmi Tikkanen; Andrew R. Wood; Peter Almgren; Mustafa Atalay; Rafn Benediktsson; Lori L. Bonnycastle; Noel Burtt; Jason Carey; Guillaume Charpentier; Andrew T. Crenshaw; Alex S. F. Doney; Mozhgan Dorkhan; Sarah Edkins; Valur Emilsson; Elodie Eury; Tom Forsen; Karl Gertow; Bruna Gigante; George B. Grant; Christopher J. Groves; Candace Guiducci; Christian Herder; Astradur B. Hreidarsson; Jennie Hui; Alan James; Anna Jonsson; Wolfgang Rathmann; Norman Klopp; Jasmina Kravic; Kaarel Krjutskov; Cordelia Langford; Karin Leander; Eero Lindholm; Stephane Lobbens; Satu Mannisto; Ghazala Mirza; Thomas W. Muehleisen; Bill Musk; Melissa Parkin; Loukianos Rallidis; Jouko Saramies; Bengt Sennblad; Sonia Shah; Gunnar Sigurdsson; Angela Silveira; Gerald Steinbach; Barbara Thorand; Joseph Trakalo; Fabrizio Veglia; Roman Wennauer; Wendy Winckler; Delilah Zabaneh; Harry Campbell; Cornelia van Duijn; Andre G. Uitterlinden; Albert Hofman; Eric Sijbrands; Goncalo R. Abecasis; Katharine R. Owen; Eleftheria Zeggini; Mieke D. Trip; Nita G. Forouhi; Ann-Christine Syvanen; Johan G. Eriksson; Leena Peltonen; Markus M. Noethen; Beverley Balkau; Colin N. A. Palmer; Valeriya Lyssenko; Tiinamaija Tuomi; Bo Isomaa; David J. Hunter; Lu Qi; Alan R. Shuldiner; Michael Roden; Ines Barroso; Tom Wilsgaard; John Beilby; Kees Hovingh; Jackie F. Price; James F. Wilson; Rainer Rauramaa; Timo A. Lakka; Lars Lind; George Dedoussis; Inger Njolstad; Nancy L. Pedersen; Kay-Tee Khaw; Nicholas J. Wareham; Sirkka M. Keinanen-Kiukaanniemi; Timo E. Saaristo; Eeva Korpi-Hyovalti; Juha Saltevo; Markku Laakso; Johanna Kuusisto; Andres Metspalu; Francis S. Collins; Karen L. Mohlke; Richard N. Bergman; Jaakko Tuomilehto; Bernhard O. Boehm; Christian Gieger; Kristian Hveem; Stephane Cauchi; Philippe Froguel; Damiano Baldassarre; Elena Tremoli; Steve E. Humphries; Danish Saleheen; John Danesh; Erik Ingelsson; Samuli Ripatti; Veikko Salomaa; Raimund Erbel; Karl-Heinz Joeckel; Susanne Moebus; Annette Peters; Thomas Illig; Ulf de Faire; Anders Hamsten; Andrew D. Morris; Peter J. Donnelly; Timothy M. Frayling; Andrew T. Hattersley; Eric Boerwinkle; Olle Melander; Sekar Kathiresan; Peter M. Nilsson; Panos Deloukas; Unnur Thorsteinsdottir; Leif C. Groop; Kari Stefansson; Frank Hu; James S. Pankow; Josee Dupuis; James B. Meigs; David Altshuler; Michael Boehnke; Mark I. McCarthy; Meta-Anal Glucose Insulin-Related

doi:10.1038/ng.2383

Back

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Journal article

Peer reviewed

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P. Morris, Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segre, Valgerdur Steinthorsdottir, Rona J. Strawbridge, Hassan Khan, Harald Grallert, Anubha Mahajan, …

Nature genetics, Vol.44(9), pp.981-+

01/09/2012

DOI: https://doi.org/10.1038/ng.2383

PMCID: PMC3442244

PMID: 22885922

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.

Metrics

1 Record Views

See more details

Details

Title: Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Creators - without role: Andrew P. Morris - University of Oxford
Benjamin F. Voight - Massachusetts Institute of Technology
Tanya M. Teslovich - Biostat
Teresa Ferreira - University of Oxford
Ayellet V. Segre - Massachusetts Institute of Technology
Valgerdur Steinthorsdottir - deCODE Genet, Reykjavik, Iceland
Rona J. Strawbridge - Karolinska Institutet
Hassan Khan - University of Cambridge
Harald Grallert - Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Neuherberg, Germany
Anubha Mahajan - University of Oxford
Inga Prokopenko - University of Oxford
Hyun Min Kang - Biostat
Christian Dina - Inserm
Tonu Esko - University of Tartu
Ross M. Fraser - University of Edinburgh
Stavroula Kanoni - Wellcome Sanger Institute
Ashish Kumar - University of Oxford
Vasiliki Lagou - University of Oxford
Claudia Langenberg - College Station Medical Center
Jian'an Luan - College Station Medical Center
Cecilia M. Lindgren - University of Oxford
Martina Mueller-Nurasyid - College Station Medical Center
Sonali Pechlivanis - University of Duisburg-Essen
N. William Rayner - University of Oxford
Laura J. Scott - Biostat
Steven Wiltshire - University of Oxford
Loic Yengo - Inst Pasteur, CNRS, UMR 8199, Inst Biol, F-59019 Lille, France
Leena Kinnunen - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Elizabeth J. Rossin - Massachusetts Institute of Technology
Soumya Raychaudhuri - Massachusetts Institute of Technology
Andrew D. Johnson - Framingham Heart Study
Antigone S. Dimas - University of Oxford
Ruth J. F. Loos - College Station Medical Center
Sailaja Vedantam - Broad Institute
Han Chen - Boston University
Jose C. Florez - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Caroline Fox - Framingham Heart Study
Ching-Ti Liu - Boston University
Denis Rybin - Boston University
David J. Couper - Biostat
Wen Hong L. Kao - Supreme Council Of Health
Man Li - Supreme Council Of Health
Marilyn C. Cornelis - Harvard University
Peter Kraft - Harvard University
Qi Sun - Harvard University
Rob M. van Dam - Harvard University
Heather M. Stringham - Biostat
Peter S. Chines - NHGRI, US Natl Inst Hlth, Bethesda, MD 20892 USA
Krista Fischer - University of Tartu
Pierre Fontanillas - Massachusetts Institute of Technology
Oddgeir L. Holmen - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Sarah E. Hunt - Wellcome Sanger Institute
Anne U. Jackson - Biostat
Augustine Kong - deCODE Genet, Reykjavik, Iceland
Robert Lawrence - University of Western Australia
Julia Meyer - Helmholtz Zentrum Muenchen, Inst Genet Epidemiol, Neuherberg, Germany
John R. B. Perry - University of Oxford
Carl G. P. Platou - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Simon Potter - Wellcome Sanger Institute
Emil Rehnberg - Karolinska Institutet
Neil Robertson - University of Oxford
Suthesh Sivapalaratnam - University of Amsterdam
Alena Stancakova - University of Eastern Finland
Kathleen Stirrups - Wellcome Sanger Institute
Gudmar Thorleifsson - deCODE Genet, Reykjavik, Iceland
Emmi Tikkanen - College Station Medical Center
Andrew R. Wood - University of Exeter
Peter Almgren - Lund University
Mustafa Atalay - University of Eastern Finland
Rafn Benediktsson - University of Iceland
Lori L. Bonnycastle - NHGRI, US Natl Inst Hlth, Bethesda, MD 20892 USA
Noel Burtt - Massachusetts Institute of Technology
Jason Carey - Massachusetts Institute of Technology
Guillaume Charpentier - Corbeil Essonnes Hosp, Endocrinol Diabetol Unit, Corbeil Essonnes, France
Andrew T. Crenshaw - Massachusetts Institute of Technology
Alex S. F. Doney - University of Dundee
Mozhgan Dorkhan - Lund University
Sarah Edkins - Wellcome Sanger Institute
Valur Emilsson - Iceland Heart Assoc, Kopavogur, Iceland
Elodie Eury - Inst Pasteur, CNRS, UMR 8199, Inst Biol, F-59019 Lille, France
Tom Forsen - University of Helsinki
Karl Gertow - Karolinska Institutet
Bruna Gigante - Karolinska Institutet
George B. Grant - Massachusetts Institute of Technology
Christopher J. Groves - University of Oxford
Candace Guiducci - Massachusetts Institute of Technology
Christian Herder - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, D-40225 Dusseldorf, Germany
Astradur B. Hreidarsson - Landspitali Univ Hosp, Dept Endocrinol & Metab, Reykjavik, Iceland
Jennie Hui - College Station Medical Center
Alan James - College Station Medical Center
Anna Jonsson - Lund University
Wolfgang Rathmann - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Biometr & Epidemiol, D-40225 Dusseldorf, Germany
Norman Klopp - Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Neuherberg, Germany
Jasmina Kravic - Lund University
Kaarel Krjutskov - University of Tartu
Cordelia Langford - Wellcome Sanger Institute
Karin Leander - Karolinska Institutet
Eero Lindholm - Lund University
Stephane Lobbens - Inst Pasteur, CNRS, UMR 8199, Inst Biol, F-59019 Lille, France
Satu Mannisto - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
Ghazala Mirza - University of Oxford
Thomas W. Muehleisen - University of Bonn
Bill Musk - College Station Medical Center
Melissa Parkin - Massachusetts Institute of Technology
Loukianos Rallidis - Univ Gen Hosp Attikon, Dept Cardiol, Athens, Greece
Jouko Saramies - S Karelia Cent Hosp, Lappeenranta, Finland
Bengt Sennblad - Karolinska Institutet
Sonia Shah - UCL, Genet Inst, Dept Genet Evolut & Environm, London, England
Gunnar Sigurdsson - Landspitali Univ Hosp, Dept Endocrinol & Metab, Reykjavik, Iceland
Angela Silveira - Karolinska Institutet
Gerald Steinbach - University of Ulm
Barbara Thorand - Helmholtz Zentrum Muenchen, Inst Epidemiol 2, Neuherberg, Germany
Joseph Trakalo - University of Oxford
Fabrizio Veglia - Centro Cardiologico Monzino
Roman Wennauer - University of Ulm
Wendy Winckler - Massachusetts Institute of Technology
Delilah Zabaneh - UCL, Genet Inst, Dept Genet Evolut & Environm, London, England
Harry Campbell - University of Edinburgh
Cornelia van Duijn - College Station Medical Center
Andre G. Uitterlinden - College Station Medical Center
Albert Hofman - College Station Medical Center
Eric Sijbrands - College Station Medical Center
Goncalo R. Abecasis - Biostat
Katharine R. Owen - University of Oxford
Eleftheria Zeggini - Wellcome Sanger Institute
Mieke D. Trip - University of Amsterdam
Nita G. Forouhi - College Station Medical Center
Ann-Christine Syvanen - Uppsala University
Johan G. Eriksson - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
Leena Peltonen
Markus M. Noethen - University of Bonn
Beverley Balkau - Inserm
Colin N. A. Palmer - University of Dundee
Valeriya Lyssenko - Lund University
Tiinamaija Tuomi - Folkhalsan Res Ctr, Helsinki, Finland
Bo Isomaa - Folkhalsan Res Ctr, Helsinki, Finland
David J. Hunter - Harvard University
Lu Qi - Harvard University
Alan R. Shuldiner - Supreme Council Of Health
Michael Roden - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, D-40225 Dusseldorf, Germany
Ines Barroso - Wellcome Sanger Institute
Tom Wilsgaard - College Station Medical Center
John Beilby - College Station Medical Center
Kees Hovingh - University of Amsterdam
Jackie F. Price - University of Edinburgh
James F. Wilson - University of Edinburgh
Rainer Rauramaa - College Station Medical Center
Timo A. Lakka - University of Eastern Finland
Lars Lind - Uppsala University
George Dedoussis - Harokopio University of Athens
Inger Njolstad - College Station Medical Center
Nancy L. Pedersen - Karolinska Institutet
Kay-Tee Khaw - University of Cambridge
Nicholas J. Wareham - College Station Medical Center
Sirkka M. Keinanen-Kiukaanniemi - University of Oulu
Timo E. Saaristo - Finnish Diabet Assoc, Tampere, Finland
Eeva Korpi-Hyovalti - College Station Medical Center
Juha Saltevo - College Station Medical Center
Markku Laakso - University of Eastern Finland
Johanna Kuusisto - University of Eastern Finland
Andres Metspalu - University of Tartu
Francis S. Collins - NHGRI, US Natl Inst Hlth, Bethesda, MD 20892 USA
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Richard N. Bergman - College Station Medical Center
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Bernhard O. Boehm - College Station Medical Center
Christian Gieger - Helmholtz Zentrum Muenchen, Inst Genet Epidemiol, Neuherberg, Germany
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Stephane Cauchi - Inst Pasteur, CNRS, UMR 8199, Inst Biol, F-59019 Lille, France
Philippe Froguel - Inst Pasteur, CNRS, UMR 8199, Inst Biol, F-59019 Lille, France
Damiano Baldassarre - Centro Cardiologico Monzino
Elena Tremoli - Centro Cardiologico Monzino
Steve E. Humphries - UCL, Inst Cardiovasc Sci, London, England
Danish Saleheen - University of Cambridge
John Danesh - University of Cambridge
Erik Ingelsson - Karolinska Institutet
Samuli Ripatti - Wellcome Sanger Institute
Veikko Salomaa - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
Raimund Erbel - University of Duisburg-Essen
Karl-Heinz Joeckel - University of Duisburg-Essen
Susanne Moebus - University of Duisburg-Essen
Annette Peters - Helmholtz Zentrum Muenchen, Inst Epidemiol 2, Neuherberg, Germany
Thomas Illig - Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Neuherberg, Germany
Ulf de Faire - Karolinska Institutet
Anders Hamsten - Karolinska Institutet
Andrew D. Morris - University of Dundee
Peter J. Donnelly - University of Oxford
Timothy M. Frayling - University of Exeter
Andrew T. Hattersley - University of Exeter
Eric Boerwinkle - Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX USA
Olle Melander - Lund University
Sekar Kathiresan - Massachusetts Institute of Technology
Peter M. Nilsson - Lund University
Panos Deloukas - Wellcome Sanger Institute
Unnur Thorsteinsdottir - deCODE Genet, Reykjavik, Iceland
Leif C. Groop - Lund University
Kari Stefansson - deCODE Genet, Reykjavik, Iceland
Frank Hu - Harvard University
James S. Pankow - University of Minnesota
Josee Dupuis - Framingham Heart Study
James B. Meigs - Harvard University
David Altshuler - Massachusetts Institute of Technology
Michael Boehnke - Biostat
Mark I. McCarthy - University of Oxford
Meta-Anal Glucose Insulin-Related
Publication Details: Nature genetics, Vol.44(9), pp.981-+
Publisher: Springer Nature
Number of pages: 12
Grant note: GR072960; 076113; 077016; 081682; 083948; 083270; 084711; 086596; 090367; 090532; 098051 / Wellcome Trust Narpes Health Care Foundation (Finland) Nord-Trondelag County Council (Norway) Munich Center of Health Sciences (MC Health) (Germany) Groupe d'Etude des Maladies Metaboliques et Systemiques (France) Karolinska Institutet (Sweden); Karolinska Institutet 4/26/2010 / Social Insurance Institution of Finland Association Francaise des Diabetiques Federal Ministry of Education and Research (BMBF) (Germany); Federal Ministry of Education & Research (BMBF) Doris Duke Charitable Foundation (USA) State of Baden-Wurttemberg, Germany General Secretary of Research and Technology (Greece) Research into Ageing (UK) Swedish Foundation for Strategic Research; Swedish Foundation for Humanities & Social Sciences University of Tromso (Norway) Heinz Nixdorf Foundation (Germany) Pfizer Food Standards Agency (UK) European Regional Development Fund; European Commission 560183; 562183 / Stockholm County Council Programme Hospitalier de Recherche Clinique (French Ministry of Health) British Diabetic Association (BDA) Research (UK) HHSN268200625226C; UL1RR025005; U01HG004399; 1R21NS064908; 1Z01HG000024; AG028555; AG08724; AG04563; AG10175; AG08861; CA055075 / US National Institutes of Health (USA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA German Center for Diabetes Research (DZD) RG/07/008/23674; RG/08/014/24067; RG/08/008/25291 / British Heart Foundation Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine and Boston Medical Center Faculty of Medicine at the Norwegian University of Science and Technology National Institute of Health Research (UK); National Institutes of Health Research (NIHR) Association de Langue Francaise pour l'Etude du Diabete et des Maladies Metaboliques (France) Harvard Medical School (USA) Stroke Association (UK) Ministry of Social Affairs and Health (Finland) Paavo Nurmi Foundation (Finland) Uppsala University (Sweden) Norwegian Institute of Public Health 8691; 09533; 2009-1039; Dnr 521-2010-3490; Dnr 521-2007-4037; Dnr 521-2008-2974; Dnr 825-2010-5983; Dnr 349-2008-6589 / Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas Helsinki University Central Hospital Research Foundation (Finland) Department of Health (UK); National Institutes of Health Research (NIHR) ER1 55/6-2 / Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) South OstroBothnia Hospital District (Finland) Ollqvist Foundation (Sweden) MRC-GSK pilot programme grant (UK); UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Sigrid Juselius Foundation (Finland); Sigrid Juselius Foundation National Genome Research Network (NGFN) (Germany) Swedish Heart-Lung Foundation City of Leutkirch (Germany) CZB/4/672 / Chief Scientist Office, Scotland European Commission (Marie Curie: FP7-PEOPLE-IEF) G0701863; G0601261; MC_UP_A100_1003; MC_PC_U127561128; G0902037 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Kuopio University Hospital (Finland) Diabetes UK Programme National de Recherche sur le Diabete (France) MT33/09 / Torsten and Ragnar Sderberg Foundation (Sweden) Great Wine Estates of the Margaret River region of Western Australia G0000649; G0601261 / Medical Research Council (UK); UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Federal Ministry of Health (Germany) Signe and Ane Gyllenberg Foundation (Sweden) 77299; 102318; 110413; 118065; 123885; 124243; 129680; 129293; 129494; 136895; 139635; 141005; 213506; 251217 / Academy of Finland; Research Council of Finland Novo Nordisk Fonden (Denmark) Center for Inherited Disease Research (CIDR) (USA) Central Norway Health Authority G0600717B; G19/35; G0100222; MC_U106179471; MC_UP_A100_1003; G0701863; G1000143; MC_PC_U127561128; G0401527; G8802774; G0601261; G0902037 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) HHSN268201100005C; HHSN268201100006C; HHSN268201100007C; HHSN268201100008C; HHSN268201100009C; HHSN268201100010C; HHSN268201100011C; HHSN268201100012C; R01HL087641; R01HL59367; R01HL086694; N01HC25195; N02HL64278 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Uppsala University Hospital (Sweden) CZB/4/710; CZB/4/672 / Chief Scientist Office Ministry of Innovation, Science, Research and Technology of North Rhine-Westphalia (Germany) Agence Nationale de la Recherche (France); Agence Nationale de la Recherche (ANR) U01HG004402; N01HG65403 / National Human Genome Research Institute (NHGRI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) Sarstedt AG Co. (Germany) Swedish Diabetes Foundation DK062370; DK058845; DK072193; DK078616; DK080140; DK073490 / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) HEALTH-F4-2007-201413 / European Commission: ENGAGE University Hospital Essen (Germany) Ministry of Health (Ricerca Corrente) (Italy) National Health Screening Service of Norway Nordic Center of Excellence in Disease Genetics City of Kuopio (Finland) Finnish Diabetes Research Foundation RG/98002; RG2008/08 / British Heart Foundation Helmholtz Zentrum Munchen-Research Center for Environment and Health (Germany) Swedish Society of Medicine Association Diabete Risque Vasculaire (France) Finnish Diabetes Association 7-08-MN-OK / American Diabetes Association Region of Nord-Pas-de-Calais (Contrat de Projets Etat-Region) (France); Region Hauts-de-France SF0180142s0 / Estonian government Finnish Foundation for Cardiovascular Research National Institute for Health and Welfare (Finland) 141005; 102318 / Academy of Finland (AKA); Research Council of Finland; Finnish Funding Agency for Technology & Innovation (TEKES) Oxford NIHR Biomedical Research Centre (UK) Foundation for Life and Health in Finland KAW 2009.0243 / Knut and Alice Wallenberg Foundation (Sweden); Knut & Alice Wallenberg Foundation DHCS/07/07/008; NF-SI-0611-10219 / National Institute for Health Research; National Institutes of Health Research (NIHR) Norwegian Research Council; Research Council of Norway Municipal Heath Care Center and Hospital, Jakobstad, Finland 627 / Ministry of Education and Culture (Finland) 359 / IngaBritt and Arne Lundberg's Research Foundation (Sweden) Swedish Cultural Foundation in Finland Central Finland Hospital District Perklen Foundation (Sweden) Royal Swedish Academy of Sciences Finnish Heart Association GRK 1041 / German Research Council; German Research Foundation (DFG) Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas Cancer Research UK Swedish Research Council for Infrastructures; Swedish Research Council; Swedish Research Council Formas Paivikki and Sakari Sohlberg Foundation (Finland) Pirkanmaa Hospital District (Finland) LSHM-CT-2004-005272; 245536; QLG1-CT-2002-00896; 2004310 / EXGENESIS; European Commission Folkhalsan Research Foundation (Finland) Slottery Machine Association (Finland)
Identifiers: 9937953608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article