Abstract
To investigate the larvicidal activities of novel anthraquinones (1a-1k) against Culex quinquefasciatus mosquito larvae. Novel anthraquinones (1a-1k) derivatives were synthesis via condensation method. The compounds were confirmed through FT-IR spectroscopy, H-1 & C-13 NMR spectrum, and mass spectral studies. The larvicidal activity of compound 1c was highly active LD50 20.92 mu g/mL against Culex quinquefasciatus compared standard permethrin with LD50 25.49 mu g/mL. Molecular docking studies were carried out for compound 1c against Odorant-binding protein of Culex quinquefasciatus. The compound 1c (-9.8 Kcal/mol) was a potent larvicide with more binding energy than control permethrin (-9.7 Kcal/mol). Therefore, compound (1c) may be more significant inhibitors of mosquito larvicidal. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.