Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

Cesar Ramos-Remus; Aldo Barajas-Ochoa; Andrea Ramirez-Gomez; Jose D. Castillo-Ortiz; Victor Brambila-Barba; Adewale O. Adebajo; Luis R. Espinoza; Francisco J. Aceves-Avila; Jorge M. Sanchez-Gonzalez; Nadia Boudersa; Samy Slimani; Aicha Ladjouze-Rezig; Monica P. Diaz; Karin I. Kirmayr; Cecilia A. Asnal; Luis J. Catoggio; Gustavo Citera; Gustavo C. Casado; Analia P. Alvarez; Cecilia N. Pisoni; Emilio Benavente; Adriana Lopez-Cabanillas; Roberto M. Baez; Bernardo A. Pons-Estel; Monica P. Sacnun; Javier A. Cavallasca; Raul H. Paniego; Susanna M. Proudman; Ranjeny Thomas; Gabor Major; David M. Mathers; Leslie Schrieber; Nazrul Islam; Syed A. Haq; Patrick H. Dessein; Carlos A. von Muhlen; Washington A. Bianchi; Geraldo da R. Castelar-Pinheiro; Daniel Feldman-Pollak; Waldenise Cossermelli; Karina R. Bonfiglioli; Rina D. Giorgi; Wendlassida J. Zabsonre-Tiendrebeogo; Lilia Olaru; Jacob Karsh; Irene H. Castro-Esparza; Carlos Fuentealba; Sergio Aguilera; Paula I. Burgos; Oscar Neira; Zhan-guo Li; Lai-Shan Tam; Mo Y. Mok; Yimy F. Medina; Andres E. Zuniga-Vera; Mario J. Moreno-Alvarez; Claudia Vera; Ivonne Quezada; Ivan M. Moreno; Wendy Calapaqui; Ghada El-Mardenly; M. Salah Salama; Gaafar Ragab; Kamel Gado; Tahsin Hadidi; Marjatta Leirisalo-Repo; Riitta Tuompo; Riitta Koivuniemi; Francis Berenbaum; Yannick Allanore; Arnaud Constantin; Frank Buttgereit; Hendrik Schulze-Koops; Myriam Liz; Dzifa Dey; Carlos B. Santiago-Pastelin; Hugo D. Alonzo-Borjas; Victor Cuellar-Cruz; Balebail G. Dharmanand; G. C. Yathish; Shashank M. Akerkar; Anand N. Malaviya; Arman Ahmadzadeh; Tomoko Hasunuma; Benard O. Owino; Cesar Pacheco-Tena; Aaron Frausto-Arenas; Adrian A. De la Madrid-Cernas; Roman Cardona-Cabrera; Juan D. Centeno-Valadez; Isaura M. Rodriguez-Torres; Binit Vaidya; Arun K. Gupta; Andrew A. Harrison; Rebecca Grainger; Henry M. Nwankwo; Andreas P. Diamantopoulos; Elisabeth Maeland; Emilio Besada; Luis Gorriz; Margarita Duarte; Sonia Cabrera-Villalba; Maria T. Romero-de Albrecht; Augusto Garcia-Poma; Maria I. Segami; Maria P. Ramos; Wilkerson Perez-Medina; Maria L. Dianongco; Juan J. Lichauco; Geraldine Z. Racaza; Sandra V. Navarra; Tito P. Torralba; Bernadette H. Manapat-Reyes; Ester G. Penserga; Mohammed Hammoudeh; Samar Al-Emadi; Anna G. Botchkova; Sabri H. AlSaeedi; Hani Almoallim; Hussein F. Al-Arfaj; Wei H. Koh; Ying Y. Leung; David A. Whitelaw; Bridget Hodkinson; Javier Garcia-Miguel; Juan C. Duro; Emilio Martin-Mola; Maria Ahijon-Lana; Jose L. Andreu; Axel Finckh; Deshire Alpizar-Rodriguez; Manathip Osiri; Nuntana Kasitanon; Worawit Louthrenoo; Ronald F. van Vollenhoven; Niek de Vries; Christiaan van Denderen; Martjin Gerritsen; Tim L. Jansen; Piet van Riel; Concepcion M. Nunez-Sotelo; Sol Villegas-Morales; GEO-RA Grp

doi:10.1007/s10067-016-3481-9

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Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

Journal article

Peer reviewed

Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

Cesar Ramos-Remus, Aldo Barajas-Ochoa, Andrea Ramirez-Gomez, Jose D. Castillo-Ortiz, Victor Brambila-Barba, Adewale O. Adebajo, Luis R. Espinoza, Francisco J. Aceves-Avila, Jorge M. Sanchez-Gonzalez, Nadia Boudersa, …

Clinical rheumatology, Vol.36(3), pp.485-497

01/03/2017

DOI: https://doi.org/10.1007/s10067-016-3481-9

PMID: 27995382

Abstract

Life Sciences & Biomedicine

Rheumatology

Science & Technology

The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10A degrees increments, south to north), longitudes (three regions), intracountry consistency, and countries' Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 +/- 14 years (95% CI 44-45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (p < 0.001, 95% CI 3.5-13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (R (2) 0.045, p < 0.001). A positive correlation was found between the age of RAO and IHDI (r = 0.7, p < 0.01, R (2) 0.5). RA often begins at an early age and onset varies across latitudes worldwide. We postulate that countries' developmental status and their geographical and geomagnetic location influence the age of RAO.

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Title: Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey
Creators - without role: Cesar Ramos-Remus - Univ Autonoma Guadalajara, Guadalajara, Jalisco, Mexico
Aldo Barajas-Ochoa - Unidad Invest Enfermedades Cronico Degenerat, Guadalajara, Jalisco, Mexico
Andrea Ramirez-Gomez - Unidad Invest Enfermedades Cronico Degenerat, Guadalajara, Jalisco, Mexico
Jose D. Castillo-Ortiz - Unidad Invest Enfermedades Cronico Degenerat, Guadalajara, Jalisco, Mexico
Victor Brambila-Barba - Unidad Invest Enfermedades Cronico Degenerat, Guadalajara, Jalisco, Mexico
Adewale O. Adebajo - University of Sheffield
Luis R. Espinoza - LSU Hlth Sci Ctr, New Orleans, LA USA
Francisco J. Aceves-Avila - Hosp Gen Reg 46, Inst Mexicano Seguro Social, Guadalajara, Jalisco, Mexico
Jorge M. Sanchez-Gonzalez - Secretaria Salud Jalisco, Guadalajara, Jalisco, Mexico
Nadia Boudersa - Dr Benbadis Univ Hosp, Constantine, Algeria
Samy Slimani - University of Batna 2
Aicha Ladjouze-Rezig - Univ Algiers, Ben Aknoun Hosp, Algiers, Algeria
Monica P. Diaz - Ctr Traumatol Bariloche, San Carlos De Bariloche, Rio Negro, Argentina
Karin I. Kirmayr - Sanatorio San Carlos, San Carlos De Bariloche, Rio Negro, Argentina
Cecilia A. Asnal - Hosp Aleman, Buenos Aires, DF, Argentina
Luis J. Catoggio - College Station Medical Center
Gustavo Citera - Inst Rehabil Psicofis, Buenos Aires, DF, Argentina
Gustavo C. Casado - Hosp Mil Cent, Buenos Aires, DF, Argentina
Analia P. Alvarez - Hosp Penna, Buenos Aires, DF, Argentina
Cecilia N. Pisoni - College Station Medical Center
Emilio Benavente - Hosp Distrito Sanitario Eva Peron 8, Formosa, Argentina
Adriana Lopez-Cabanillas - Roca
Roberto M. Baez - Roca
Bernardo A. Pons-Estel - Inst Cardiovasc Rosario, Rosario, Argentina
Monica P. Sacnun - Hosp Prov Rosario, Rosario, Argentina
Javier A. Cavallasca - Hosp JB Iturraspe, Secc Reumatol & Enfermedades Autoimmunes, Santa Fe, Argentina
Raul H. Paniego - Ctr Privado Rehabil, Santa Rosa, Argentina
Susanna M. Proudman - University of Adelaide
Ranjeny Thomas - University of Queensland
Gabor Major - Bone & Joint Inst Royal New Castle Ctr, Newcastle, NSW, Australia
David M. Mathers - Georgetown Arthrit, Newcastle, NSW, Australia
Leslie Schrieber - Royal North Shore Hosp, Dept Rheumatol, Inst Bone & Joint Res, Kolling Inst, Sydney, NSW, Australia
Nazrul Islam - Bangabandhu Sheikh MujibMed Univ, Dept Rheumatol, Dhaka, Bangladesh
Syed A. Haq - Bangabandhu Sheikh MujibMed Univ, Dept Rheumatol, Dhaka, Bangladesh
Patrick H. Dessein - Univ Hosp Brussels, Div Rheumatol, Brussels, Belgium
Carlos A. von Muhlen - Rheuma Clin, Porto Alegre, RS, Brazil
Washington A. Bianchi - Supreme Council Of Health
Geraldo da R. Castelar-Pinheiro - Univ Estado Rio de Janeiro, Rio De Janeiro, Brazil
Daniel Feldman-Pollak - Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
Waldenise Cossermelli - Supreme Council Of Health
Karina R. Bonfiglioli - College Station Medical Center
Rina D. Giorgi - HSPE FMO, Serv Reumatol, Sao Paulo, Brazil
Wendlassida J. Zabsonre-Tiendrebeogo - Univ Ouagadougou, Ctr Hosp Univ Yalgado Ouedraogo, Ouagadougou, Burkina Faso
Lilia Olaru - University of Alberta
Jacob Karsh - Ottawa Hosp, Ottawa, ON, Canada
Irene H. Castro-Esparza - University of Concepción
Carlos Fuentealba - Hosp Clin San Borja Arriaran, Santiago, Chile
Sergio Aguilera - University of Chile
Paula I. Burgos - Pontificia Univ Catolica Chile, Santiago, Chile
Oscar Neira - University of Chile
Zhan-guo Li - Supreme Council Of Health
Lai-Shan Tam - Chinese University of Hong Kong
Mo Y. Mok - City University of Hong Kong
Yimy F. Medina - Univ Nacl Colombia, Bogota, Colombia
Andres E. Zuniga-Vera - Hosp Luis Vernaza, Guayaquil, Ecuador
Mario J. Moreno-Alvarez - Hosp Luis Vernaza, Guayaquil, Ecuador
Claudia Vera - Univ Catolica Guayaquil, Guayaquil, Ecuador
Ivonne Quezada - Hosp Especialidades Eugenio Espejo, Quito, Ecuador
Ivan M. Moreno - Clin Santa Lucia, Quito, Ecuador
Wendy Calapaqui - Ctr Atenc Ambulatoria El Batan IESS, Quito, Ecuador
Ghada El-Mardenly - Cairo University
M. Salah Salama - Ain Shams University
Gaafar Ragab - Cairo University
Kamel Gado - Cairo University
Tahsin Hadidi - Ctr Rheumatol, Cairo, Egypt
Marjatta Leirisalo-Repo - Helsinki Univ Hosp, Dept Rheumatol, Helsinki, Finland
Riitta Tuompo - Helsinki Univ Hosp, Dept Rheumatol, Helsinki, Finland
Riitta Koivuniemi - Kanta Hame Hosp, Riihimaki, Finland
Francis Berenbaum - Marie Curie
Yannick Allanore - Paris Descartes University
Arnaud Constantin - Hop Purpan, Ctr Rhumatol, Toulouse, France
Frank Buttgereit - Charité - Universitätsmedizin Berlin
Hendrik Schulze-Koops - College Station Medical Center
Myriam Liz - College Station Medical Center
Dzifa Dey - University of Ghana
Carlos B. Santiago-Pastelin - Inst Hondureno Seguridad Social, Tegucigalpa, Honduras
Hugo D. Alonzo-Borjas - Inst Hondureno Seguridad Social, Tegucigalpa, Honduras
Victor Cuellar-Cruz - Inst Hondureno Seguridad Social, Tegucigalpa, Honduras
Balebail G. Dharmanand - Sakra World Hosp, Inst Rheumatol & Autoimmune Disorders, Bangalore, Karnataka, India
G. C. Yathish - College Station Medical Center
Shashank M. Akerkar - Mumbai Arthrit Clin, Mumbai, Maharashtra, India
Anand N. Malaviya - ISIC Superspecial Hosp, Dept Rheumatol, New Delhi, India
Arman Ahmadzadeh - Shahid Beheshti University
Tomoko Hasunuma - Cent Clin, Tokyo, Japan
Benard O. Owino - Kenyatta Natl Hosp, Nairobi, Kenya
Cesar Pacheco-Tena - College Station Medical Center
Aaron Frausto-Arenas - College Station Medical Center
Adrian A. De la Madrid-Cernas - University of Colima
Roman Cardona-Cabrera - Ctr Reumatol Queretaro, Queretaro, Mexico
Juan D. Centeno-Valadez - Inst Mexicano Seguro Social, Hermosillo, Sonora, Mexico
Isaura M. Rodriguez-Torres - Unidad Enfermedades Reumat & Cron Degenerat, Torreon, Mexico
Binit Vaidya - Natl Ctr Rheumat Dis, Kathmandu, Nepal
Arun K. Gupta - Natl Ctr Rheumat Dis, Kathmandu, Nepal
Andrew A. Harrison - University of Otago
Rebecca Grainger - University of Otago
Henry M. Nwankwo - Nnamdi Azikiwe University
Andreas P. Diamantopoulos - Hosp Rheumat Dis, Dept Rheumatol, Haugesund, Norway
Elisabeth Maeland - Hosp Rheumat Dis, Dept Rheumatol, Haugesund, Norway
Emilio Besada - UiT The Arctic University of Norway
Luis Gorriz - Hosp Santo Tomas, Panama City, Panama
Margarita Duarte - Univ Nacl Asuncion, Hosp Clin, Asuncion, Paraguay
Sonia Cabrera-Villalba - Univ Nacl Asuncion, Hosp Clin, Asuncion, Paraguay
Maria T. Romero-de Albrecht - Sanatorio Santa Clara, Asuncion, Paraguay
Augusto Garcia-Poma - Hosp Carlos Alcantara B, Lima, Peru
Maria I. Segami - EsSALUD
Maria P. Ramos - EsSALUD
Wilkerson Perez-Medina - EsSALUD
Maria L. Dianongco - Mécanique et Engrenage Moderne
Juan J. Lichauco - College Station Medical Center
Geraldine Z. Racaza - College Station Medical Center
Sandra V. Navarra - University of Santo Tomas
Tito P. Torralba - University of Santo Tomas
Bernadette H. Manapat-Reyes - Univ Philippines, Philippine Gen Hosp, Manila, Philippines
Ester G. Penserga - Univ Philippines, Philippine Gen Hosp, Manila, Philippines
Mohammed Hammoudeh - College Station Medical Center
Samar Al-Emadi - College Station Medical Center
Anna G. Botchkova - Agat
Sabri H. AlSaeedi - College Station Medical Center
Hani Almoallim - Netaji Subhas National Institute of Sports
Hussein F. Al-Arfaj - King Saud University
Wei H. Koh - College Station Medical Center
Ying Y. Leung - Singapore Gen Hosp, Dept Rheumatol & Immunol, Singapore, Singapore
David A. Whitelaw - Tygerberg Hosp, Bellville, South Africa
Bridget Hodkinson - University of Cape Town
Javier Garcia-Miguel - Hosp Univ Sagrat Cor, Barcelona, Spain
Juan C. Duro - Clin Pilar, IDC Salud, Rheumatol Unit, Barcelona, Spain
Emilio Martin-Mola - Hosp Univ La Paz, Dept Rheumatol, Madrid, Spain
Maria Ahijon-Lana - Hosp Cent Def Gomez Ulla, Madrid, Spain
Jose L. Andreu - Hosp Univ Puerta Hierro, Majadahonda, Spain
Axel Finckh - Univ Hosp Geneva, Geneva, Switzerland
Deshire Alpizar-Rodriguez - Univ Hosp Geneva, Geneva, Switzerland
Manathip Osiri - Chulalongkorn University
Nuntana Kasitanon - Chiang Mai University
Worawit Louthrenoo - Chiang Mai University
Ronald F. van Vollenhoven - Wisconsin Disability Association
Niek de Vries - College Station Medical Center
Christiaan van Denderen - Amsterdam Rheumatol & Immunol Ctr ARC, Reade Inst, Amsterdam, Netherlands
Martjin Gerritsen - Amsterdam Rheumatol & Immunol Ctr ARC, Reade Inst, Amsterdam, Netherlands
Tim L. Jansen - College Station Medical Center
Piet van Riel - Bernhoven, Dept Rheumatol, Uden, Netherlands
Concepcion M. Nunez-Sotelo - Univ Ctr Occidental Lisandro Alvarado, Clin Razetti Barquisimeto, Barquisimeto, Venezuela
Sol Villegas-Morales - Hosp Vargas Caracas, Serv Reumatol, Caracas, Venezuela
GEO-RA Grp
Publication Details: Clinical rheumatology, Vol.36(3), pp.485-497
Publisher: Springer Nature
Number of pages: 13
Identifiers: 9931483408331
Academic Unit: Umm Al Qura University; King Saud University
Language: English
Resource Type: Journal article