Abstract
A series of N-substituted morpholines 2-20 was synthesised by reacting various acid chlorides and alkyl halides with morpholine (1). All of the synthesised compounds 2-20 were screened for their leishmanicidal effects using amphotericin B (IC50 = 0.24 g L-1) and pentamidine (IC50 = 2.56 g mL-1) as standards and a structure-activity relationship (SAR) study was established. The compounds 2 (IC50 = 48 g mL-1), 3 (IC50 = 30.0 g mL-1), 10 (IC50 = 41.0 g mL-1), 15 (IC50 = 33.0 g mL-1), 16 (IC50 = 35.0 g mL-1) and 20 (IC50 = 47.0 g mL-1) showed weak leishmanicidal activities.