Abstract
Cutaneous adverse reactions induced by drugs are common. They occur in 1% to 3% of drugs users. The aim of this study is to determine the frequency of cutaneous adverse drug reactions, describe the clinical aspects of these reactions and determine the scores of imputability relating the possible drug-effect relationship in Morocco. This is a prospective study of cutaneous adverse drug reactions occurring in patients in El Idrissi hospital in Kenitra during the period April 2012-April 2013. The analysis of cause-effect relationships between the drug and the occurrence of clinical and paraclinical effects is conducted by the French causality assessment method with 7 scores from 0 to 6. The most common types of cutaneous adverse reactions were urticaria and skin eruptions. The French method of imputability gave the following results: 64.04% of drug-effect relationships had an imputability score of 12, 15.79% a score of 11, 14.91% a score of 13, 3.51% a score of 14 and 1.75% a score of 10. Cutaneous adverse drug reactions must be recognized in advance in order to ensure better surveillance and improve the safety of drugs.