Ligand-free copper-mediated N-arylation of spirocyclic lactams

Wei Yang; Ana Luisa Coutinho; Atef A. Abdel-Hafez; Chao Jiang; Fengtian Xue

doi:10.1016/j.tetlet.2015.08.051

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Ligand-free copper-mediated N-arylation of spirocyclic lactams

Journal article

Peer reviewed

Ligand-free copper-mediated N-arylation of spirocyclic lactams

Wei Yang, Ana Luisa Coutinho, Atef A. Abdel-Hafez, Chao Jiang and Fengtian Xue

Tetrahedron letters, Vol.56(41), pp.5599-5603

07/10/2015

DOI: https://doi.org/10.1016/j.tetlet.2015.08.051

Abstract

Copper catalyst

Diffuse large B-cell lymphoma

Goldberg coupling

N-Aryl spirocyclic lactam

Triple negative breast cancer

[Display omitted] We report a ligand-free copper-catalyzed Goldberg coupling of a spirocyclic lactam with an aryl iodide or bromide to provide an N-aryl spirocyclic lactam in good to excellent yields. The protocol is applicable to a broad diversity of spirocyclic lactams. The corresponding products can be used for the preparation of tetra- and pent-cyclic compounds 4–7 as potential therapeutic agents in the treatment of diffuse large B-cell lymphoma (DLBCL) and triple negative breast cancer (TNBC).

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Title: Ligand-free copper-mediated N-arylation of spirocyclic lactams
Creators - without role: Wei Yang - University of Maryland, Baltimore
Ana Luisa Coutinho - University of Maryland, Baltimore
Atef A. Abdel-Hafez - University of Maryland, Baltimore
Chao Jiang - Nanjing University of Science and Technology
Fengtian Xue - University of Maryland, Baltimore
Publication Details: Tetrahedron letters, Vol.56(41), pp.5599-5603
Publisher: Elsevier Ltd
Identifiers: 9928751908331
Academic Unit: Qassim University
Language: English
Resource Type: Journal article