Ligations from Tyrosine Isopeptides via 12-to 19-Membered Cyclic Transition States

Vadim Popov; Siva S. Panda; Alan R. Katritzky

doi:10.1021/jo4009468

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Ligations from Tyrosine Isopeptides via 12-to 19-Membered Cyclic Transition States

Journal article

Peer reviewed

Ligations from Tyrosine Isopeptides via 12-to 19-Membered Cyclic Transition States

Vadim Popov, Siva S. Panda and Alan R. Katritzky

Journal of organic chemistry, Vol.78(15), pp.7455-7461

02/08/2013

DOI: https://doi.org/10.1021/jo4009468

PMID: 23758522

Abstract

Chemistry

Chemistry, Organic

Physical Sciences

Science & Technology

Efficient syntheses of O-acyl Tyr-peptides allow chemical long-range ligation (O-acyl to N-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from O-acyl Tyr-peptides.

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Title: Ligations from Tyrosine Isopeptides via 12-to 19-Membered Cyclic Transition States
Creators - without role: Vadim Popov - University of Florida
Siva S. Panda - University of Florida
Alan R. Katritzky - University of Florida
Publication Details: Journal of organic chemistry, Vol.78(15), pp.7455-7461
Publisher: Amer Chemical Soc
Number of pages: 7
Grant note: KAU D-006/431 / King Abdulaziz University University of Florida Kenan Foundation
Identifiers: 9939087008331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article