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Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11-and 12-membered cyclic transition states
Journal article   Peer reviewed

Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11-and 12-membered cyclic transition states

Vadim Popov, Siva S. Panda and Alan R. Katritzky
Organic & biomolecular chemistry, Vol.11(10), pp.1594-1597
13/02/2013
DOI: https://doi.org/10.1039/c3ob27421g
PMID: 23361377

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units.

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