Abstract
Aim: Function of thyroid gland is regulating a wide array of metabolic activities which have direct impact on some parameters. The objective of this study was to see the effect of thyroid dysfunction on serum lipid profile parameters among the people of Bastar region. Material and Method: Blood samples were collected from 60 subjects. The blood was analyzed for the levels of thyroid stimulating hormone (TSH), tri-iodothyroinine (T3), tetra-iodothyronine (T4), free tri-iodothyronine (FT3), free tetraiodothyronine (FT4) by microplate immune enzymetric assay. Patients with thyroid dysfunction were categorized into hypothyroid and hyperthyroid with increased and decreased levels of TSH respectively. Levels of total cholesterol (TC), triacylglycerol (Tg), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were measured, and compared between normal and patients with thyroid dysfunction. Results: Elevated levels of TC, Tg, LDL-C, VLDL-C, TC/HDL ratio, and significantly decreased HDL-C were observed in hypothyroid patients. Hyperthyroid patients revealed low HDL-C levels with no significant changes in TC, Tg, LDL-C, VLDL-C, and TC/HDL ratio. Analysis of variance (ANOVA) showed the significant difference among all the groups and Tukey's honest test revealed the significant difference in the mean values of the biochemical parameters in all groups at 0.05 level of significance. Discussion: As there is a controversy regarding effect of thyroid dysfunction on lipid profile, the present work was conducted on thyroid dysfunction tribal patients of Bastar, and compared with the normal subjects. The study concluded increased lipid profile in hypothyroid subjects and found no effect on the lipid profile of hyperthyroid subjects.