Abstract
An efficient and general method has been developed for the synthesis of 1-(2-phenothiazinyl)3-aryl-2-propen-1-ones 3a-k from 2-acetylphenothiazine and aromatic aldehydes using lithium hydroxide monohydrate as an efficient and dual activation catalyst. The antioxidant activity of the synthesized compounds was evaluated using the procedure developed by Lissi et al. Compounds 3a, 3e, and 3g were found to be highly potent antioxidant. Furthermore, compounds 3a, 3e, and 3g have an ability to protect DNA from the induced damage by bleomycin.
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