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Long-term response in a patient with ITP following low dose anti-D immunoglobulin therapy
Journal article   Peer reviewed

Long-term response in a patient with ITP following low dose anti-D immunoglobulin therapy

N A Smith, R K Chakraverty, D Obeid and B J Boughton
Autoimmunity (Chur, Switzerland), Vol.4(1-2), pp.115-117
1989
DOI: https://doi.org/10.3109/08916938909034366
PMID: 2562380

Abstract

Blood Platelets - immunology Child Female Humans Immunoglobulins - administration & dosage Macrophages - immunology Purpura, Thrombocytopenic - blood Purpura, Thrombocytopenic - immunology Purpura, Thrombocytopenic - therapy Receptors, Fc Rh-Hr Blood-Group System Rho(D) Immune Globulin
A patient with chronic ITP relapsed after conventional therapy but following an infusion with low dose anti D (Rho) immunoglobulin, she entered a remission which has now lasted 10 months. This is difficult to explain on the basis of long term macrophage Fc receptor blockade and suggests an alternative mechanism of action.

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