Abstract
Orally disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The aim of the present work was to formulate orally disintegrating tablets of lorasatan potassium for hypertensive patients. A taste masking agent; Eudragit E100, was mixed with losartan and microcrystalline cellulose (MCC) at different ratios to form a composite prior to direct compression, and the effect of formula composition on drug dissolution was studied. Thereafter, tablets were prepared by direct compression technique using three superdisintegrants. The effect of superdisintegrants and the taste masking agent on disintegration time and dissolution rate was studied. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, in vitro disintegration and in vitro dissolution. It was found that all manufactured tablets were within the official limits according to USP. The drug release was increased by addition of superdisintegrant. The highest drug release was from F5, which contains crosscarmulose sodium as superdisintegrant. Tablets containing taste masking agent showed acceptable taste and mouth feel. The results obtained conclusively demonstrated successful rapid disintegration of the formulated tablets and acceptable in vivo patient palatability.