Lymph Node Involvement and the Clinical Stage as Predictors of the Survival of Patients With Adenoid Cystic Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis

Mazin Alsarraj; Sami M Alshehri; Abdulrahman Qattan; Abdelelah Mofti; Lana Wazqer; Sumayiah Bukhari; Aisha Shamsaldin; Rahaf Rajab

doi:10.7759/cureus.30780

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Lymph Node Involvement and the Clinical Stage as Predictors of the Survival of Patients With Adenoid Cystic Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis

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Lymph Node Involvement and the Clinical Stage as Predictors of the Survival of Patients With Adenoid Cystic Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis

Mazin Alsarraj, Sami M Alshehri, Abdulrahman Qattan, Abdelelah Mofti, Lana Wazqer, Sumayiah Bukhari, Aisha Shamsaldin and Rahaf Rajab

Curēus (Palo Alto, CA), Vol.14(10), pp.e30780-e30780

27/10/2022

DOI: https://doi.org/10.7759/cureus.30780

PMID: 36447733

Abstract

adenoid cystic carcinoma (acc)

head and neck tumors

lymph node status

Otolaryngology

salivary gland tumor

stage

In the treatment of various patients, the presence of lymphovascular invasion is a prognostic determinant, often taken into account by surgeons and oncologists. The exact frequency and prognostic impacts of this microscopic event in adenoid cystic carcinoma (ACC) patients are, however, not clear. This systematic review and meta-analysis aimed to investigate the lymph node involvement and the clinical stage of cancer as predictors of ACC prognosis. A systematic search was conducted covering a number of databases, including PubMed, Science Direct, Google Scholar, Web of Science, and EBSCO. A total of three studies were included in this analysis, with 591 participants, 247 of whom were males. Lymph node involvement and clinical stage were demonstrated as significant bad prognosis factors among ACC patients (HR = 1.48, 95% CI, 1.00, 1.96; P<0.0001). We found that lymph node involvement and clinical stage of the cancer are both significant predictors of bad prognosis of ACC.

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Title: Lymph Node Involvement and the Clinical Stage as Predictors of the Survival of Patients With Adenoid Cystic Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis
Creators - without role: Mazin Alsarraj - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Sami M Alshehri - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Abdulrahman Qattan - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Abdelelah Mofti - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Lana Wazqer - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Sumayiah Bukhari - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Aisha Shamsaldin - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Rahaf Rajab - Otolaryngology - Head and Neck Surgery, King Fahad General Hospital, Jeddah, SAU Otolaryngology - Head and Neck Surgery, King Abdullah Medical Complex, Jeddah, SAU Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU
Publication Details: Curēus (Palo Alto, CA), Vol.14(10), pp.e30780-e30780
Publisher: Cureus
Identifiers: 9933137708331
Academic Unit: University of Jeddah; Imam Abdulrahman Bin Faisal University
Language: English
Resource Type: Journal article