Abstract
Introduction: Vitiligo is a relatively common autoimmune pathology that causes disfigurement and leads to negative impact of the self-esteem and quality of life. Generally, vitiligo is known to be a result of several factors including genetic and environmental factors.
Aim of work: In this review, we aim to discuss recent advances in the treatment modalities of vitiligo.
Methods: We did a systematic search for vitiligo using PubMed and Google Scholar search engines. The terms used in the search were: vitiligo, pathophysiology, mechanisms, management, treatment, recent modalities.
Conclusions: Treatment vitiligo consists of three main phases: stop the spread of the disease, recover damaged areas, and prevent relapses. Several treatment modalities have been used to achieve these three phases. However, no current protocol achieves all three phases completely. Systemic corticosteroids and methotrexate have been successfully used in stopping the spread of the disease. Phototherapy, topical steroids, and intralesional steroids have all been use to induce repigmentation in damaged lesions. However, no treatment until now has provided satisfactory declines in relapse rates. Several new treatments are being tested and developed for vitiligo like topical prostaglandins therapy.