Abstract
The purpose of thsi study was to provide some benzimidazole derivatives as angiotensin converting enzyme (ACE) inhibitor. Based on the literature, a total of 19 benzimidazole derivates were selected for molecular modelling study using the Autodock Vina software. The molecular modelling revealed that compound 10,16, and 18 had binding affinity with th ACe enzyme closer to the binding affinity of lisinopril. To obtain the compounds 10, 16 and 18, the 2-(butylsulfanyl)- lH-benzumidazole was treated with 2-fluorophencylbromide, 2-methylphenacylbromide, and 3-nitrophenacylbromide, respectively. The structures of these compounds were confirmed on the basis of their spectral data (IR, H-1-NMR, and C-13-NMR). The synthesized compounds were subjected for their in vitro ACE inhibitory assy using Dojindo ACE Ku-WST test kit. Dojindo Laboratories, Kumamoto, Japan. It was observed that the compounds 10 and 16 had IC50 values less than the standard drug Lisinopril and have the required attributes to become potential candidates as an ACE inhibitor. However, further studies are recommended to ensure their efficacy and safety in different animal models.