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Male-pattern baldness susceptibility locus at 20p11
Journal article   Peer reviewed

Male-pattern baldness susceptibility locus at 20p11

J. Brent Richards, Xin Yuan, Frank Geller, Dawn Waterworth, Veronique Bataille, Daniel Glass, Kijoung Song, Gerard Waeber, Peter Vollenweider, Katja K. H. Aben, …
Nature genetics, Vol.40(11), pp.1282-1284
01/11/2008
DOI: https://doi.org/10.1038/ng.255
PMCID: PMC2672151
PMID: 18849991

Abstract

Genetics & Heredity Life Sciences & Biomedicine Science & Technology
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

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