Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani

Pramila Chaubey; Brahmeshwar Mishra; Shyam Lal Mudavath; Ravi R. Patel; Sundeep Chaurasia; Shyam Sundar; Vasanti Suvarna; Marvis Monteiro

doi:10.1016/j.ijbiomac.2017.12.143

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Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani

Journal article

Peer reviewed

Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani

Pramila Chaubey, Brahmeshwar Mishra, Shyam Lal Mudavath, Ravi R. Patel, Sundeep Chaurasia, Shyam Sundar, Vasanti Suvarna and Marvis Monteiro

International journal of biological macromolecules, Vol.111, pp.109-120

01/05/2018

DOI: https://doi.org/10.1016/j.ijbiomac.2017.12.143

PMID: 29307805

Abstract

Curcumin

Macrophages

Mannose-conjugated chitosan

Nanoparticles

Visceral leishmaniasis

Aim was to fabricate and optimize CUR-loaded mannose-functionalized chitosan nanoparticles (Cur-MCN) which overcome the limitations of drugs to reach the intracellular locations and to establish its therapeutic potential in visceral leishmaniasis by targeting of CUR to macrophages. Cur-MCN were developed by mannose-conjugated chitosan and have been tested for their efficacy and toxicit. In vivo antileishmanial activity in hamsters has shown significantly greater suppression of parasite replication in the spleen with Cur-MCN than unconjugated chitosan nanoparticles. The in vitro cytotoxicity study against the J774A.1 cell line demonstrated its comparative non-toxicity towards the macrophage cells. The potential of Cur-MCN was also confirmed by minimal observed cytotoxicity in our in vivo studies. [Display omitted]

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Title: Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani
Creators - without role: Pramila Chaubey - Banaras Hindu University
Brahmeshwar Mishra - Banaras Hindu University
Shyam Lal Mudavath - India Habitat Centre
Ravi R. Patel - Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, Uttar Pradesh, India
Sundeep Chaurasia - Banaras Hindu University
Shyam Sundar - Banaras Hindu University
Vasanti Suvarna - Department of Pharmaceutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mithibai College Campus, Vile Parle, Mumbai, Maharashtra, India
Marvis Monteiro - Shri Vile Parle Kelavani Mandal
Publication Details: International journal of biological macromolecules, Vol.111, pp.109-120
Publisher: Elsevier B.V
Identifiers: 9929315308331
Academic Unit: Shaqra University
Language: English
Resource Type: Journal article