Mapping Human Genetic Diversity in Asia

Mahmood Ameen Abdulla; Ikhlak Ahmed; Anunchai Assawamakin; Jong Bhak; Samir K. Brahmachari; Gayvelline C. Calacal; Amit Chaurasia; Chien-Hsiun Chen; Jieming Chen; Yuan-Tsong Chen; Jiayou Chu; Eva Maria C. Cutiongco-de la Paz; Maria Corazon A. De Ungria; Frederick C. Delfin; Juli Edo; Suthat Fuchareon; Ho Ghang; Takashi Gojobori; Junsong Han; Sheng-Feng Ho; Boon Peng Hoh; Wei Huang; Hidetoshi Inoko; Pankaj Jha; Timothy A. Jinam; Li Jin; Jongsun Jung; Daoroong Kangwanpong; Jatupol Kampuansai; Giulia C. Kennedy; Preeti Khurana; Hyung-Lae Kim; Kwangjoong Kim; Sangsoo Kim; Woo-Yeon Kim; Kuchan Kimm; Ryosuke Kimura; Tomohiro Koike; Supasak Kulawonganunchai; Vikrant Kumar; Poh San Lai; Jong-Young Lee; Sunghoon Lee; Edison T. Liu; Partha P. Majumder; Kiran Kumar Mandapati; Sangkot Marzuki; Wayne Mitchell; Mitali Mukerji; Kenji Naritomi; Chumpol Ngamphiw; Norio Niikawa; Nao Nishida; Bermseok Oh; Sangho Oh; Jun Ohashi; Akira Oka; Rick Ong; Carmencita D. Padilla; Prasit Palittapongarnpim; Henry B. Perdigon; Maude Elvira Phipps; Eileen Png; Yoshiyuki Sakaki; Jazelyn M. Salvador; Yuliana Sandraling; Vinod Scaria; Mark Seielstad; Mohd Ros Sidek; Amit Sinha; Metawee Srikummool; Herawati Sudoyo; Sumio Sugano; Helena Suryadi; Yoshiyuki Suzuki; Kristina A. Tabbada; Adrian Tan; Katsushi Tokunaga; Sissades Tongsima; Lilian P. Villamor; Eric Wang; Ying Wang; Haifeng Wang; Jer-Yuarn Wu; Huasheng Xiao; Shuhua Xu; Jin Ok Yang; Yin Yao Shugart; Hyang-Sook Yoo; Wentao Yuan; Guoping Zhao; Bin Alwi Zilfalil; HUGO Pan Asian SNP Consortium

doi:10.1126/science.1177074

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Journal article

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Mapping Human Genetic Diversity in Asia

Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak, Samir K. Brahmachari, Gayvelline C. Calacal, Amit Chaurasia, Chien-Hsiun Chen, Jieming Chen, Yuan-Tsong Chen, …

Science (American Association for the Advancement of Science), Vol.326(5959), pp.1541-1545

11/12/2009

DOI: https://doi.org/10.1126/science.1177074

PMID: 20007900

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

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Title: Mapping Human Genetic Diversity in Asia
Creators - without role: Mahmood Ameen Abdulla - University of Malaya
Ikhlak Ahmed - Central Food Technological Research Institute
Anunchai Assawamakin - Mahidol University
Jong Bhak - Korea Research Institute of Bioscience and Biotechnology
Samir K. Brahmachari - Central Food Technological Research Institute
Gayvelline C. Calacal - University of the Philippines System
Amit Chaurasia - Central Food Technological Research Institute
Chien-Hsiun Chen - Academia Sinica
Jieming Chen - Agency for Science, Technology and Research
Yuan-Tsong Chen - Academia Sinica
Jiayou Chu - Chinese Academy of Medical Sciences & Peking Union Medical College
Eva Maria C. Cutiongco-de la Paz - University of the Philippines Manila
Maria Corazon A. De Ungria - University of the Philippines System
Frederick C. Delfin - University of the Philippines System
Juli Edo - University of Malaya
Suthat Fuchareon - Mahidol University
Ho Ghang - Korea Research Institute of Bioscience and Biotechnology
Takashi Gojobori - National Institute of Advanced Industrial Science and Technology
Junsong Han - Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China
Sheng-Feng Ho - Academia Sinica
Boon Peng Hoh - Universiti Sains Malaysia
Wei Huang - Chinese National Human Genome Center
Hidetoshi Inoko - Tokai University
Pankaj Jha - Central Food Technological Research Institute
Timothy A. Jinam - University of Malaya
Li Jin - Fudan University
Jongsun Jung - Korea Natl Inst Hlth, Seoul 122701, South Korea
Daoroong Kangwanpong - Chiang Mai University
Jatupol Kampuansai - Chiang Mai University
Giulia C. Kennedy - Thermo Fisher Scientific
Preeti Khurana - Central Food Technological Research Institute
Hyung-Lae Kim - Korea Natl Inst Hlth, Seoul 122701, South Korea
Kwangjoong Kim - Korea Natl Inst Hlth, Seoul 122701, South Korea
Sangsoo Kim - Soongsil University
Woo-Yeon Kim - Korea Research Institute of Bioscience and Biotechnology
Kuchan Kimm - Eulji University
Ryosuke Kimura - The University of Tokyo
Tomohiro Koike - Res Org Informat & Syst, Ctr Informat Biol, Mishima, Shizuoka 4118540, Japan
Supasak Kulawonganunchai - National Science and Technology Development Agency
Vikrant Kumar - Agency for Science, Technology and Research
Poh San Lai - National University of Singapore
Jong-Young Lee - Korea Natl Inst Hlth, Seoul 122701, South Korea
Sunghoon Lee - KRIBB, KOBIC, Taejon 305806, South Korea
Edison T. Liu - Agency for Science, Technology and Research
Partha P. Majumder - Indian Statistical Institute
Kiran Kumar Mandapati - Central Food Technological Research Institute
Sangkot Marzuki - Eijkman Institute for Molecular Biology
Wayne Mitchell - Agency for Science, Technology and Research
Mitali Mukerji - Central Food Technological Research Institute
Kenji Naritomi - University of the Ryukyus
Chumpol Ngamphiw - National Science and Technology Development Agency
Norio Niikawa - Health Sciences University of Hokkaido
Nao Nishida - The University of Tokyo
Bermseok Oh - Korea Natl Inst Hlth, Seoul 122701, South Korea
Sangho Oh - KRIBB, KOBIC, Taejon 305806, South Korea
Jun Ohashi - The University of Tokyo
Akira Oka - Tokai University
Rick Ong - Genome Institute of Singapore
Carmencita D. Padilla - University of the Philippines System
Prasit Palittapongarnpim - National Science and Technology Development Agency
Henry B. Perdigon - University of the Philippines System
Maude Elvira Phipps - Monash University Malaysia
Eileen Png - Agency for Science, Technology and Research
Yoshiyuki Sakaki - RIKEN
Jazelyn M. Salvador - University of the Philippines System
Yuliana Sandraling - Eijkman Institute for Molecular Biology
Vinod Scaria - Central Food Technological Research Institute
Mark Seielstad - Agency for Science, Technology and Research
Mohd Ros Sidek - Universiti Sains Malaysia
Amit Sinha - Central Food Technological Research Institute
Metawee Srikummool - Chiang Mai University
Herawati Sudoyo - Eijkman Institute for Molecular Biology
Sumio Sugano - The University of Tokyo
Helena Suryadi - Eijkman Institute for Molecular Biology
Yoshiyuki Suzuki - Res Org Informat & Syst, Ctr Informat Biol, Mishima, Shizuoka 4118540, Japan
Kristina A. Tabbada - University of the Philippines System
Adrian Tan - Agency for Science, Technology and Research
Katsushi Tokunaga - The University of Tokyo
Sissades Tongsima - National Science and Technology Development Agency
Lilian P. Villamor - University of the Philippines System
Eric Wang - Thermo Fisher Scientific
Ying Wang - Chinese National Human Genome Center
Haifeng Wang - Chinese National Human Genome Center
Jer-Yuarn Wu - Academia Sinica
Huasheng Xiao - Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China
Shuhua Xu - Max
Jin Ok Yang - Korea Research Institute of Bioscience and Biotechnology
Yin Yao Shugart - National Institutes of Health
Hyang-Sook Yoo - Korea Research Institute of Bioscience and Biotechnology
Wentao Yuan - Chinese National Human Genome Center
Guoping Zhao - Chinese National Human Genome Center
Bin Alwi Zilfalil - Universiti Sains Malaysia
HUGO Pan Asian SNP Consortium
Publication Details: Science (American Association for the Advancement of Science), Vol.326(5959), pp.1541-1545
Publisher: Amer Assoc Advancement Science
Number of pages: 5
Identifiers: 9945776308331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article