Abstract
Bisphenol A (BPA) is suspected to be associated with several chronic metabolic diseases. The aim of the present study was to examine the associations of urinary BPA concentrations, with cardio metabolic risk factors including: age, gender, lipid profile, High-sensitivity C-reactive protein (hs-CRP) levels among children and adolescents. It's a cross-sectional study enrolling 167 children; 95boys and 72girls. They aged from 6 to 16 years, randomly selected from primary, and preparatory schools in Giza, Egypt. All participants were subjected to thorough clinical examination, Anthropometric measurements. Urinary Bisphenol A was detected by high performance liquid chromatography-tandem mass spectrometry (HPLC) then total, conjugated, unconjugated, log total, BPA/creatinine and log BPA/creatinine were estimated. Serum samples were assayed for total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and High-sensitivity C-reactive protein (hs-CRP).Results: Participants mean age was 11.70 +/- 3.08,while mean weight and height, was 53.63+/- 22.47, 149.09 +/-17.99, respectively. Serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and hs-CRP) showed no statistically significant differences as regard to age and gender (P> 0.05).No significant association between BPA and the age, gender was found(P>0.05).Total BPA/creatinine ratio was significantly positively correlated with the serum total cholesterol and LDL-cholesterol (P<0.05).We did not find significant associations between BPA and any other cardiovascular risk factors. Our work provides additional evidence of associations between urinary BPA and cardiovascular risk factors among Egyptian children and adolescents.Future policy regulating children's consumer products is mandatory.