Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Iris M. Heid; Anne U. Jackson; Joshua C. Randall; Thomas W. Winkler; Lu Qi; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; M. Carola Zillikens; Elizabeth K. Speliotes; Reedik Maegi; Tsegaselassie Workalemahu; Charles C. White; Nabila Bouatia-Naji; Tamara B. Harris; Sonja I. Berndt; Erik Ingelsson; Cristen J. Willer; Michael N. Weedon; Jianan Luan; Sailaja Vedantam; Tonu Esko; Tuomas O. Kilpelaeinen; Zoltan Kutalik; Shengxu Li; Keri L. Monda; Anna L. Dixon; Christopher C. Holmes; Lee M. Kaplan; Liming Liang; Josine L. Min; Miriam F. Moffatt; Cliona Molony; George Nicholson; Eric E. Schadt; Krina T. Zondervan; Mary F. Feitosa; Teresa Ferreira; Hana Lango Allen; Robert J. Weyant; Eleanor Wheeler; Andrew R. Wood; Karol Estrada; Michael E. Goddard; Guillaume Lettre; Massimo Mangino; Dale R. Nyholt; Shaun Purcell; Albert Vernon Smith; Peter M. Visscher; Jian Yang; Steven A. McCarroll; James Nemesh; Benjamin F. Voight; Devin Absher; Najaf Amin; Thor Aspelund; Lachlan Coin; Nicole L. Glazer; Caroline Hayward; Nancy L. Heard-Costa; Jouke-Jan Hottenga; Asa Johansson; Toby Johnson; Marika Kaakinen; Karen Kapur; Shamika Ketkar; Joshua W. Knowles; Peter Kraft; Aldi T. Kraja; Claudia Lamina; Michael F. Leitzmann; Barbara McKnight; Andrew P. Morris; Ken K. Ong; John R. B. Perry; Marjolein J. Peters; Ozren Polasek; Inga Prokopenko; Nigel W. Rayner; Samuli Ripatti; Fernando Rivadeneira; Neil R. Robertson; Serena Sanna; Ulla Sovio; Ida Surakka; Alexander Teumer; Sophie van Wingerden; Veronique Vitart; Jing Hua Zhao; Christine Cavalcanti-Proenca; Peter S. Chines; Eva Fisher; Jennifer R. Kulzer; Cecile Lecoeur; Narisu Narisu; Camilla Sandholt; Laura J. Scott; Kaisa Silander; Klaus Stark; Mari-Liis Tammesoo; Tanya M. Teslovich; Nicholas John Timpson; Richard M. Watanabe; Ryan Welch; Daniel I. Chasman; Matthew N. Cooper; John-Olov Jansson; Johannes Kettunen; Robert W. Lawrence; Niina Pellikka; Markus Perola; Liesbeth Vandenput; Helene Alavere; Peter Almgren; Larry D. Atwood; Amanda J. Bennett; Reiner Biffar; Lori L. Bonnycastle; Stefan R. Bornstein; Thomas A. Buchanan; Harry Campbell; Ian N. M. Day; Mariano Dei; Marcus Doerr; Paul Elliott; Michael R. Erdos; Johan G. Eriksson; Nelson B. Freimer; Mao Fu; Stefan Gaget; Eco J. C. Geus; Anette P. Gjesing; Harald Grallert; Juergen Graessler; Christopher J. Groves; Candace Guiducci; Anna-Liisa Hartikainen; Neelam Hassanali; Aki S. Havulinna; Karl-Heinz Herzig; Andrew A. Hicks; Jennie Hui; Wilmar Igl; Pekka Jousilahti; Antti Jula; Eero Kajantie; Leena Kinnunen; Ivana Kolcic; Seppo Koskinen; Peter Kovacs; Heyo K. Kroemer; Vjekoslav Krzelj; Johanna Kuusisto; Kirsti Kvaloy; Jaana Laitinen; Olivier Lantieri; G. Mark Lathrop; Marja-Liisa Lokki; Robert N. Luben; Barbara Ludwig; Wendy L. McArdle; Anne McCarthy; Mario A. Morken; Mari Nelis; Matt J. Neville; Guillaume Pare; Alex N. Parker; John F. Peden; Irene Pichler; Kirsi H. Pietilainen; Carl G. P. Platou; Anneli Pouta; Martin Ridderstrale; Nilesh J. Samani; Jouko Saramies; Juha Sinisalo; Jan H. Smit; Rona J. Strawbridge; Heather M. Stringham; Amy J. Swift; Maris Teder-Laving; Brian Thomson; Gianluca Usala; Joyce B. J. van Meurs; Gert-Jan van Ommen; Vincent Vatin; Claudia B. Volpato; Henri Wallaschofski; G. Bragi Walters; Elisabeth Widen; Sarah H. Wild; Gonneke Willemsen; Daniel R. Witte; Lina Zgaga; Paavo Zitting; John P. Beilby; Alan L. James; Mika Kahonen; Terho Lehtimaki; Markku S. Nieminen; Claes Ohlsson; Lyle J. Palmer; Olli Raitakari; Paul M. Ridker; Michael Stumvoll; Anke Toenjes; Jorma Viikari; Beverley Balkau; Yoav Ben-Shlomo; Richard N. Bergman; Heiner Boeing; George Davey Smith; Shah Ebrahim; Philippe Froguel; Torben Hansen; Christian Hengstenberg; Kristian Hveem; Bo Isomaa; Torben Jorgensen; Fredrik Karpe; Kay-Tee Khaw; Markku Laakso; Debbie A. Lawlor; Michel Marre; Thomas Meitinger; Andres Metspalu; Kristian Midthjell; Oluf Pedersen; Veikko Salomaa; Peter E. H. Schwarz; Tiinamaija Tuomi; Jaakko Tuomilehto; Timo T. Valle; Nicholas J. Wareham; Alice M. Arnold; Jacques S. Beckmann; Sven Bergmann; Eric Boerwinkle; Dorret I. Boomsma; Mark J. Caulfield; Francis S. Collins; Gudny Eiriksdottir; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Andrew T. Hattersley; Albert Hofman; Frank B. Hu; Thomas Illig; Carlos Iribarren; Marjo-Riitta Jarvelin; W. H. Linda Kao; Jaakko Kaprio; Lenore J. Launer; Patricia B. Munroe; Ben Oostra; Brenda W. Penninx; Peter P. Pramstaller; Bruce M. Psaty; Thomas Quertermous; Aila Rissanen; Igor Rudan; Alan R. Shuldiner; Nicole Soranzo; Timothy D. Spector; Ann-Christine Syvanen; Manuela Uda; Andre Uitterlinden; Henry Voelzke; Peter Vollenweider; James F. Wilson; Jacqueline C. Witteman; Alan F. Wright; Goncalo R. Abecasis; Michael Boehnke; Ingrid B. Borecki; Panos Deloukas; Timothy M. Frayling; Leif C. Groop; Talin Haritunians; David J. Hunter; Robert C. Kaplan; Kari E. North; Jeffrey R. O'Connell; Leena Peltonen; David Schlessinger; David P. Strachan; Joel N. Hirschhorn; Themistocles L. Assimes; H-Erich Wichmann; Unnur Thorsteinsdottir; Cornelia M. van Duijn; Kari Stefansson; L. Adrienne Cupples; Ruth J. F. Loos; Ines Barroso; Mark I. McCarthy; Caroline S. Fox; Karen L. Mohlke; Cecilia M. Lindgren; MAGIC

doi:10.1038/ng.685

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Iris M. Heid, Anne U. Jackson, Joshua C. Randall, Thomas W. Winkler, Lu Qi, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, M. Carola Zillikens, Elizabeth K. Speliotes, Reedik Maegi, …

Nature genetics, Vol.42(11), pp.949-U160

01/11/2010

DOI: https://doi.org/10.1038/ng.685

PMCID: PMC3000924

PMID: 20935629

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 x 10(-9) to P = 1.8 x 10(-40)) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 x 10(-3) to P = 1.2 x 10(-13)). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

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Title: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Creators - without role: Iris M. Heid - College Station Medical Center
Anne U. Jackson - Biostat
Joshua C. Randall - University of Oxford
Thomas W. Winkler - College Station Medical Center
Lu Qi - Harvard University
Valgerdur Steinthorsdottir - deCODE Genet, Reykjavik, Iceland
Gudmar Thorleifsson - deCODE Genet, Reykjavik, Iceland
M. Carola Zillikens - College Station Medical Center
Elizabeth K. Speliotes - Broad Institute
Reedik Maegi - University of Oxford
Tsegaselassie Workalemahu - Harvard University
Charles C. White - Boston University
Nabila Bouatia-Naji - Inst Pasteur, IBL, UMR8199, CNRS, F-59019 Lille, France
Tamara B. Harris - NIA, Lab Epidemiol, NIH, Bethesda, MD 20892 USA
Sonja I. Berndt - NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
Erik Ingelsson - Karolinska Institutet
Cristen J. Willer - Biostat
Michael N. Weedon - University of Exeter
Jianan Luan - Massachusetts Rehabilitation Commission
Sailaja Vedantam - Broad Institute
Tonu Esko - University of Tartu
Tuomas O. Kilpelaeinen - Massachusetts Rehabilitation Commission
Zoltan Kutalik - University of Lausanne
Shengxu Li - Massachusetts Rehabilitation Commission
Keri L. Monda - Supreme Council Of Health
Anna L. Dixon - University of Bath
Christopher C. Holmes - Mary Lyon Centre at MRC Harwell
Lee M. Kaplan - Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA
Liming Liang - Harvard University
Josine L. Min - Leiden University
Miriam F. Moffatt - University of London
Cliona Molony - Merck & Co Inc, Merck Res Labs, Boston, MA USA
George Nicholson - University of Oxford
Eric E. Schadt - Menlo School
Krina T. Zondervan - Wellcome Trust
Mary F. Feitosa - Supreme Council Of Health
Teresa Ferreira - University of Oxford
Hana Lango Allen - University of Exeter
Robert J. Weyant - Biostat
Eleanor Wheeler - Wellcome Sanger Institute
Andrew R. Wood - University of Exeter
Karol Estrada - College Station Medical Center
Michael E. Goddard - University of Melbourne
Guillaume Lettre - Montreal Heart Institute
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Dale R. Nyholt - College Station Medical Center
Shaun Purcell - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Albert Vernon Smith - Iceland Heart Assoc, Kopavogur, Iceland
Peter M. Visscher - College Station Medical Center
Jian Yang - College Station Medical Center
Steven A. McCarroll - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
James Nemesh - MIT, Cambridge, MA 02139 USA
Benjamin F. Voight - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Devin Absher - Association of Local Public Health Agencies
Najaf Amin - Erasmus MC
Thor Aspelund - Iceland Heart Assoc, Kopavogur, Iceland
Lachlan Coin - University of London
Nicole L. Glazer - University of Washington
Caroline Hayward - College Station Medical Center
Nancy L. Heard-Costa - Boston University
Jouke-Jan Hottenga - University of Amsterdam
Asa Johansson - Uppsala University
Toby Johnson - University of Lausanne
Marika Kaakinen - University of Oulu
Karen Kapur - University of Lausanne
Shamika Ketkar - Supreme Council Of Health
Joshua W. Knowles - Stanford University
Peter Kraft - Harvard University
Aldi T. Kraja - Supreme Council Of Health
Claudia Lamina - Helmholtz Zentrum München
Michael F. Leitzmann - College Station Medical Center
Barbara McKnight - University of Washington
Andrew P. Morris - University of Oxford
Ken K. Ong - Massachusetts Rehabilitation Commission
John R. B. Perry - University of Exeter
Marjolein J. Peters - College Station Medical Center
Ozren Polasek - University of Zagreb
Inga Prokopenko - University of Oxford
Nigel W. Rayner - University of Oxford
Samuli Ripatti - University of Helsinki
Fernando Rivadeneira - College Station Medical Center
Neil R. Robertson - University of Oxford
Serena Sanna - Ist Neurogenet & Neurofarmacol CNR, Cagliari, Italy
Ulla Sovio - University of London
Ida Surakka - University of Helsinki
Alexander Teumer - University of Greifswald
Sophie van Wingerden - Erasmus MC
Veronique Vitart - College Station Medical Center
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Christine Cavalcanti-Proenca - Inst Pasteur, IBL, UMR8199, CNRS, F-59019 Lille, France
Peter S. Chines - NHGRI, NIH, Bethesda, MD 20892 USA
Eva Fisher - German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany
Jennifer R. Kulzer - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Cecile Lecoeur - Inst Pasteur, IBL, UMR8199, CNRS, F-59019 Lille, France
Narisu Narisu - NHGRI, NIH, Bethesda, MD 20892 USA
Camilla Sandholt - Hagedorn Res Inst, Gentofte, Denmark
Laura J. Scott - Biostat
Kaisa Silander - University of Helsinki
Klaus Stark - University of Regensburg
Mari-Liis Tammesoo - University of Tartu
Tanya M. Teslovich - Biostat
Nicholas John Timpson - Avon
Richard M. Watanabe - Supreme Council Of Health
Ryan Welch - Biostat
Daniel I. Chasman - Harvard University
Matthew N. Cooper - University of Western Australia
John-Olov Jansson - University of Gothenburg
Johannes Kettunen - University of Helsinki
Robert W. Lawrence - University of Western Australia
Niina Pellikka - University of Helsinki
Markus Perola - University of Helsinki
Liesbeth Vandenput - University of Gothenburg
Helene Alavere - University of Tartu
Peter Almgren - Lund University
Larry D. Atwood - Boston University
Amanda J. Bennett - University of Oxford
Reiner Biffar - Zentrum Zahn Mund & Kieferheilkunde, Greifswald, Germany
Lori L. Bonnycastle - NHGRI, NIH, Bethesda, MD 20892 USA
Stefan R. Bornstein - College Station Medical Center
Thomas A. Buchanan - Supreme Council Of Health
Harry Campbell - University of Edinburgh
Ian N. M. Day - Avon
Mariano Dei - Ist Neurogenet & Neurofarmacol CNR, Cagliari, Italy
Marcus Doerr - University of Greifswald
Paul Elliott - University of London
Michael R. Erdos - NHGRI, NIH, Bethesda, MD 20892 USA
Johan G. Eriksson - University of Helsinki
Nelson B. Freimer - Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA
Mao Fu - Supreme Council Of Health
Stefan Gaget - Inst Pasteur, IBL, UMR8199, CNRS, F-59019 Lille, France
Eco J. C. Geus - University of Amsterdam
Anette P. Gjesing - Hagedorn Res Inst, Gentofte, Denmark
Harald Grallert - Helmholtz Zentrum München
Juergen Graessler - College Station Medical Center
Christopher J. Groves - University of Oxford
Candace Guiducci - Broad Institute
Anna-Liisa Hartikainen - University of Oulu
Neelam Hassanali - University of Oxford
Aki S. Havulinna - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki, Finland
Karl-Heinz Herzig - University of Oulu
Andrew A. Hicks - College Station Medical Center
Jennie Hui - University of Western Australia
Wilmar Igl - Uppsala University
Pekka Jousilahti - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki, Finland
Antti Jula - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Populat Studies Unit, Turku, Finland
Eero Kajantie - Natl Inst Hlth & Welf, Helsinki, Finland
Leena Kinnunen - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Ivana Kolcic - University of Zagreb
Seppo Koskinen - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki, Finland
Peter Kovacs - Univ Leipzig, Interdisciplinary Ctr Clin Res, Leipzig, Germany
Heyo K. Kroemer - University of Greifswald
Vjekoslav Krzelj - University of Split
Johanna Kuusisto - College Station Medical Center
Kirsti Kvaloy - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Jaana Laitinen - Finnish Inst Occupat Hlth, Oulu, Finland
Olivier Lantieri - Inst Interreg Sante IRSA, La Riche, France
G. Mark Lathrop - Ctr Natl Genotypage, Paris, France
Marja-Liisa Lokki - University of Helsinki
Robert N. Luben - University of Cambridge
Barbara Ludwig - College Station Medical Center
Wendy L. McArdle - University of Bristol
Anne McCarthy - Res Board, Div Hlth, Dublin, Ireland
Mario A. Morken - NHGRI, NIH, Bethesda, MD 20892 USA
Mari Nelis - University of Tartu
Matt J. Neville - University of Oxford
Guillaume Pare - McMaster University
Alex N. Parker - Amgen
John F. Peden - University of Oxford
Irene Pichler - College Station Medical Center
Kirsi H. Pietilainen - University of Helsinki
Carl G. P. Platou - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Anneli Pouta - University of Oulu
Martin Ridderstrale - Lund University
Nilesh J. Samani - University of Leicester
Jouko Saramies - S Karelia Cent Hosp, Lappeenranta, Finland
Juha Sinisalo - University of Helsinki
Jan H. Smit - University of Amsterdam
Rona J. Strawbridge - Karolinska Institutet
Heather M. Stringham - Biostat
Amy J. Swift - NHGRI, NIH, Bethesda, MD 20892 USA
Maris Teder-Laving - Estonian Bioctr, Tartu, Estonia
Brian Thomson - Broad Institute
Gianluca Usala - Ist Neurogenet & Neurofarmacol CNR, Cagliari, Italy
Joyce B. J. van Meurs - College Station Medical Center
Gert-Jan van Ommen - Leiden University
Vincent Vatin - Inst Pasteur, IBL, UMR8199, CNRS, F-59019 Lille, France
Claudia B. Volpato - College Station Medical Center
Henri Wallaschofski - University of Greifswald
G. Bragi Walters - deCODE Genet, Reykjavik, Iceland
Elisabeth Widen - University of Helsinki
Sarah H. Wild - University of Edinburgh
Gonneke Willemsen - University of Amsterdam
Daniel R. Witte - Steno Diabet Ctr, DK-2820 Gentofte, Denmark
Lina Zgaga - University of Zagreb
Paavo Zitting - Lapland Cent Hosp, Dept Physiatr, Rovaniemi, Finland
John P. Beilby - College Station Medical Center
Alan L. James - College Station Medical Center
Mika Kahonen - University of Tampere
Terho Lehtimaki - Tampere University
Markku S. Nieminen - University of Helsinki
Claes Ohlsson - University of Gothenburg
Lyle J. Palmer - University of Western Australia
Olli Raitakari - University of Turku
Paul M. Ridker - Harvard University
Michael Stumvoll - College Station Medical Center
Anke Toenjes - College Station Medical Center
Jorma Viikari - University of Turku
Beverley Balkau - Inserm
Yoav Ben-Shlomo - University of Bristol
Richard N. Bergman - Supreme Council Of Health
Heiner Boeing - German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany
George Davey Smith - Avon
Shah Ebrahim - Supreme Council Of Health
Philippe Froguel - Inst Pasteur, IBL, UMR8199, CNRS, F-59019 Lille, France
Torben Hansen - Hagedorn Res Inst, Gentofte, Denmark
Christian Hengstenberg - University of Regensburg
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Bo Isomaa - Folkhalsan Res Ctr, Helsinki, Finland
Torben Jorgensen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Fredrik Karpe - University of Oxford
Kay-Tee Khaw - University of Cambridge
Markku Laakso - College Station Medical Center
Debbie A. Lawlor - Avon
Michel Marre - Assistance Publique – Hôpitaux de Paris
Thomas Meitinger - Tech Univ Munich, Klinikum Rechts Isar, Inst Human Genet, D-8000 Munich, Germany
Andres Metspalu - University of Tartu
Kristian Midthjell - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway
Oluf Pedersen - Hagedorn Res Inst, Gentofte, Denmark
Veikko Salomaa - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki, Finland
Peter E. H. Schwarz - College Station Medical Center
Tiinamaija Tuomi - Folkhalsan Res Ctr, Helsinki, Finland
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Timo T. Valle - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
Alice M. Arnold - University of Washington
Jacques S. Beckmann - University of Lausanne
Sven Bergmann - University of Lausanne
Eric Boerwinkle - College Station Medical Center
Dorret I. Boomsma - University of Amsterdam
Mark J. Caulfield - Queen Mary University of London
Francis S. Collins - NHGRI, NIH, Bethesda, MD 20892 USA
Gudny Eiriksdottir - Iceland Heart Assoc, Kopavogur, Iceland
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Ulf Gyllensten - Uppsala University
Anders Hamsten - Karolinska Institutet
Andrew T. Hattersley - University of Exeter
Albert Hofman - NGI, NCHA, Rotterdam, Netherlands
Frank B. Hu - Harvard University
Thomas Illig - Helmholtz Zentrum München
Carlos Iribarren - Kaiser Permanente
Marjo-Riitta Jarvelin - University of London
W. H. Linda Kao - Supreme Council Of Health
Jaakko Kaprio - University of Helsinki
Lenore J. Launer - NIA, Lab Epidemiol, NIH, Bethesda, MD 20892 USA
Patricia B. Munroe - Queen Mary University of London
Ben Oostra - Erasmus MC
Brenda W. Penninx - University of Amsterdam
Peter P. Pramstaller - College Station Medical Center
Bruce M. Psaty - University of Washington
Thomas Quertermous - Stanford University
Aila Rissanen - University of Helsinki
Igor Rudan - University of Edinburgh
Alan R. Shuldiner - Supreme Council Of Health
Nicole Soranzo - Wellcome Sanger Institute
Timothy D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Ann-Christine Syvanen - Uppsala University
Manuela Uda - Ist Neurogenet & Neurofarmacol CNR, Cagliari, Italy
Andre Uitterlinden - College Station Medical Center
Henry Voelzke - College Station Medical Center
Peter Vollenweider - University of Lausanne
James F. Wilson - University of Edinburgh
Jacqueline C. Witteman - NGI, NCHA, Rotterdam, Netherlands
Alan F. Wright - College Station Medical Center
Goncalo R. Abecasis - Biostat
Michael Boehnke - Biostat
Ingrid B. Borecki - Supreme Council Of Health
Panos Deloukas - Wellcome Sanger Institute
Timothy M. Frayling - University of Exeter
Leif C. Groop - Lund University
Talin Haritunians - College Station Medical Center
David J. Hunter - Harvard University
Robert C. Kaplan - Albert Einstein College of Medicine
Kari E. North - Supreme Council Of Health
Jeffrey R. O'Connell - Supreme Council Of Health
Leena Peltonen - Wellcome Sanger Institute
David Schlessinger - NIA, Genet Lab, Baltimore, MD 21224 USA
David P. Strachan - University of London
Joel N. Hirschhorn - Broad Institute
Themistocles L. Assimes - Stanford University
H-Erich Wichmann - Helmholtz Zentrum München
Unnur Thorsteinsdottir - deCODE Genet, Reykjavik, Iceland
Cornelia M. van Duijn - NGI, NCHA, Rotterdam, Netherlands
Kari Stefansson - deCODE Genet, Reykjavik, Iceland
L. Adrienne Cupples - Boston University
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Ines Barroso - Wellcome Sanger Institute
Mark I. McCarthy - University of Oxford
Caroline S. Fox - Framingham Heart Study
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Cecilia M. Lindgren - University of Oxford
MAGIC
Publication Details: Nature genetics, Vol.42(11), pp.949-U160
Publisher: Springer Nature
Number of pages: 14
Grant note: Torsten and Ragnar Soderberg's Foundation Social Ministry of the Federal State of Mecklenburg-West Pomerania, Germany Danish Pharmaceutical Association Finska Lakaresallskapet 014-93-015 / Research Institute for Diseases in the Elderly Support for Science Funding programme National Health and Medical Research Council of Australia and the Great Wine Estates Auctions; National Health and Medical Research Council (NHMRC) of Australia Vastra Gotaland Foundation ALF/LUA Gothenburg 33CSCO-122661 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF) Healthway, Western Australia 560183 / Karolinska Institute and the Stockholm County Council; Karolinska Institutet 97020; PG/02/128 / British Heart Foundation Municipal Health Care Center and Hospital in Jakobstad South Tyrol Ministry of Health Fondation LeDucq; Leducq Foundation Swedish Foundation for Strategic Research (SSF); Swedish Foundation for Strategic Research Neuroscience Campus Amsterdam Emil and Vera Cornell Foundation Finnish Diabetes Research Society Yrjo Jahnsson Foundation CamStrad Signe and Ane Gyllenberg Foundation Finnish Foundation for Pediatric Research University Hospital Medical National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Lundberg Foundation Ib Henriksen Foundation Western Australian Genetic Epidemiology Resource Petrus and Augusta Hedlunds Foundation Helsinki University Central Hospital Augustinus Foundation Med Drive Turku University Hospitals Pew Scholarship for the Biomedical Sciences SF0180142s08 / Estonian Government 01GS0823; FKZ 01GS0823 / German National Genome Research Net NGFN2 and NGFNplus Netherlands Ministry for Health Novo Nordisk Foundation; Novocure Limited Paivikki and Sakari Sohlberg Foundation Paavo Nurmi Foundation 213225; 216374; 129418; 210595; 129568; 114382 / Academy of Finland (AKA); Research Council of Finland Dresden University of Technology Ollqvist Foundation G0000649; G0601261; G9521010D; G0000934; G0500539; G0600331 / Medical Research Council UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Ministry of Cultural Affairs of the Federal State of Mecklenburg-West Pomerania, Germany Amgen Health care center in Nerpes Narpes Health Care Foundation Health care center in Korsholm Busselton Population Medical Research Foundation Danish Ministry of Internal Affairs and Health 8691; K2007-66X-20270-01-3; K2010-54X-09894-19-3 / Swedish Medical Research Council; Swedish Medical Research Council (SMRC) Danish Heart Foundation A305:188 / Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR) Swedish Heart-Lung Foundation Becket Foundation Netherlands Genomics Initiative Diabetes UK 104781; 120315; 129269; 117797; 121584; 126925; 129418; 129568; 77299; 124243; 129680; 129494; 10404; 213506; 114382; 126775; 127437; 129255; 129306; 130326; 209072; 210595; 213225; 216374 / Academy of Finland; Research Council of Finland University and Research of the Autonomous Province of Bolzano Gyllenberg Foundation Royal Swedish Academy of Science G0801056; G0500115; MC_U106179472; MC_U106188470; MC_UP_A390_1107; MC_U127561128; G0600331; G0601261; G0000934; G0600705; G0501184; MC_qA137934 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) British Diabetic Association Research Montreal Heart Institute Foundation NF-SI-0508-10212 / National Institute for Health Research; National Institutes of Health Research (NIHR) 050-060-810 / Netherlands Consortium Federal State of Mecklenburg-West Pomerania 75617 / University Hospital Oulu, Biocenter, University of Oulu, Finland Finnish Ministry of Education 01 AK 803 A-H; 01 IG 07015 G / German Bundesministerium fuer Forschung und Technology Hjartavernd (the Icelandic Heart Association) Erasmus Medical Center and Erasmus University, Rotterdam, The Netherlands; Netherlands Government B27 / IZKF MRC Centre for Obesity-Related Metabolic Disease; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Perklen Foundation Welfare and Sports UK Department of Health Policy Research Programme Danish Diabetes Association Knut Krohn, Microarray Core Facility of the Interdisciplinary Centre for Clinical Research (IZKF), University of Leipzig, Germany Biomedicum Helsinki Foundation CZB/4/710 / Chief Scientist Office GEN-AU 'GOLD' from Austria 077016/Z/05/Z; 068545/Z/02; 072960; 076113; 083270; 085301; 079557; 081682; 075491; 076113/B/04/Z; 091746/Z/10/Z; 079895; WT086596/Z/08/Z / Wellcome Trust National Institute for Health Research (NIHR); National Institutes of Health Research (NIHR) Sigrid Juselius Foundation Helmholtz Center Munich; Helmholtz Association 216-1080315-0302 / Ministry of Science, Education and Sport of the Republic of Croatia; Ministry of Science, Education and Sports, Republic of Croatia Juvenile Diabetes Research Foundation International (JDRF); Juvenile Diabetes Research Foundation AstraZeneca AB; AstraZeneca 01ZZ9603; 01ZZ0103; 01ZZ0403; 03ZIK012; 01 EA 9401 / Federal Ministry of Education and Research, Germany; Federal Ministry of Education & Research (BMBF) Danish Centre for Health Technology Assessment EMGO+ institute MC Health Lundbeck Foundation Centre of Applied Medical Genomics Folkhalsan Research Foundation DK46200 / Boston Obesity Nutrition Research Center Novo Nordisk Inc.; Novo Nordisk Social Insurance Institution of Finland State of Bavaria, Germany Finnish Medical Society 2004310; 212111; 205419; 245536; DG XII; HEALTH-F4-2007-201413; FP7/2007-2013; QLG1-CT-2000-01643; QLG2-CT-2002-01254; LSHG-CT-2006-018947; LSHG-CT-2006-01947; LSHG-CT-2004-512066; LSHM-CT-2007-037273; EU/WLRT-2001-01254; LSHG-CT-2004-518153; SOC 95201408 05F02 / European Commission; European Commission Joint Research Centre Contrat Plan Etat Region de France N02-HL-6-4278 / ADA; American Diabetes Association Goteborg Medical Society SPI 56-464-1419 / Netherlands Centre for Medical Systems Biology DIAB Core (German Network of Diabetes) Jalmari and Rauha Ahokas Foundation CA047988; CA65725; CA87969; CA49449; CA67262; CA50385; DK075787; DK062370; DK58845; DK072193; K23-DK080145; K99HL094535; N01-HC85079; N01-HC85086; N01-HG-65403; N01-AG-12100; N01-HC-25195; N01-HC35129; N01-HC15103; N01-HC55222; N01-HC75150; N01-HC45133; N01-HC55015; N01-HC55016; N01-HC-55018; N01-HC-55019; N01-HC-55020; N01-HC-55021; N01-HC-55022; N01-AG-1-2109; HL71981; HG005581; HG002651; HL084729; HL043851; HHSN268200625226C; MH084698; P30-DK072488; R01 HL087652; R01-HL087641; R01-HL59367; R01-HL086694; R01-HL087647; R01-HL087679; R01-HL087700; R01-AG031890; R01-HL088119; R01-DK068336; R01-DK075681; R01-DK-073490; R01-DK075787; R01-MH63706; U01-HL72515; U01-GM074518; U01-HL084756; U01-HG004399; UO1-CA098233; UL1-RR025005; U01-HG004402; U01-DK062418; U01 HL080295; T32-HG00040; 263-MA-410953; 1RL1-MH083268-01; 1Z01-HG000024 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Royal Society Finnish Foundation of Cardiovascular Research Finnish Diabetes Research Foundation Municipality of Rotterdam South Tyrolean Sparkasse Foundation Althingi (the Icelandic Parliament) Chief Scientist Office of the Scottish Government Swedish Society of Medicine Western Australian DNA Bank (both National Health and Medical Research Council of Australia Enabling Facilities) Donald W. Reynolds Foundation 1192 / British Diabetes Association; Diabetes UK Foundation for Life and Health in Finland KFO-152 / German Research Council; German Research Foundation (DFG) Knut and Alice Wallenberg Foundation; Knut & Alice Wallenberg Foundation Swedish Cultural Foundation in Finland Biocentrum Helsinki Fond Europeen pour le Developpement Regional Cambridge NIHR Comprehensive Biomedical Research Centre Netherlands Ministry of Education, Culture and Science Siemens Healthcare, Erlangen, Germany; Siemens AG G0600331; G0000934; G0801056B; G0501184; G0401527; MC_U106188470; G0500115; MC_U127561128; MC_qA137934; G0801056; MC_U106179472; G0601261; G0600705; MC_UP_A390_1107 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Health Care Center in Vasa 175.010.2005.011; 911-03-012; 904-61-090; 904-61-193; 480-04-004; 400-05-717 / Netherlands Organisation of Scientific Research Netherlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) Investments; Netherlands Organization for Scientific Research (NWO) GlaxoSmithKline Juho Vainio Foundation Danish Research Council; Det Frie Forskningsrad (DFF) Research Foundation of Copenhagen County
Identifiers: 9936625808331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article