Sign in
Back
"Metal-free" synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives
Journal article   Peer reviewed

"Metal-free" synthesis of 1,2,3-triazoles via tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of ethyl acrylate derivatives

B. Senthil Kumar, Sunita Gadakh and Arumugam Sudalai
Tetrahedron letters, Vol.59(24), pp.2365-2367
13/06/2018
DOI: https://doi.org/10.1016/j.tetlet.2018.05.020

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An efficient "one-pot" method for the synthesis of substituted 1,2,3-triazole derivatives in excellent yields as single regioisomer is reported. The key transformation involves an atom-efficient tandem azidation, intramolecular [3+2]-cycloaddition and aromatization of acrylate derivatives on treatment with NaN3 in DMF under mild conditions. (C) 2018 Elsevier Ltd. All rights reserved.

Metrics

1 Record Views

Details