Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase

Akhtar Muhammad; Itrat Anis; Zulfiqar Ali; Sufyan Awadelkarim; Ajmal Khan; Asaad Khalid; Muhammad Raza Shah; M. Galal; Ikhlas A. Khan; M. Iqbal Choudhary

doi:10.1016/j.bmcl.2011.10.072

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Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase

Journal article

Peer reviewed

Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase

Akhtar Muhammad, Itrat Anis, Zulfiqar Ali, Sufyan Awadelkarim, Ajmal Khan, Asaad Khalid, Muhammad Raza Shah, M. Galal, Ikhlas A. Khan and M. Iqbal Choudhary

Bioorganic & medicinal chemistry letters, Vol.22(1), pp.610-612

01/01/2012

DOI: https://doi.org/10.1016/j.bmcl.2011.10.072

PMID: 22082562

Abstract

Chemistry

Chemistry, Medicinal

Chemistry, Organic

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Physical Sciences

Science & Technology

A new methylene-bridged bisflavonoid, methylenebissantin (1), and nine known compounds, including flavonoids (2-5), diterpenoids (6 and 7), and phenol derivatives (8-10) were isolated from the aerial parts of Dodonaea viscosa Jacq. The structure elucidation was based on spectroscopic data analyses. The isolated compounds were evaluated for the inhibition of Plasmodium falciparum enoyl-ACP reductase (PfENR). Methylenebissantin (1) exhibited a moderate inhibition (IC50 91.13 mu M) against PfENR. (C) 2011 Elsevier Ltd. All rights reserved.

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Title: Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase
Creators - without role: Akhtar Muhammad - University of Karachi
Itrat Anis - University of Karachi
Zulfiqar Ali - International Center for Chemical and Biological Sciences
Sufyan Awadelkarim - National Centre for Research
Ajmal Khan - International Center for Chemical and Biological Sciences
Asaad Khalid - National Centre for Research
Muhammad Raza Shah - International Center for Chemical and Biological Sciences
M. Galal - National Centre for Research
Ikhlas A. Khan - University of Mississippi
M. Iqbal Choudhary - King Saud University
Publication Details: Bioorganic & medicinal chemistry letters, Vol.22(1), pp.610-612
Publisher: Elsevier
Number of pages: 3
Grant note: University of Karachi 70/HEJ-MAPRI / Islamic Development Bank, Jeddah, K.S.A.
Identifiers: 9916934808331
Academic Unit: Jazan University
Language: English
Resource Type: Journal article