Abstract
Herein, we have accounted the interaction of an antidepressant drug amitriptyline hydrochloride (AMT) with nonionic surfactant (TX-100) in aqueous solutions using different spectroscopic techniques. The difference in structure of the AMT and TX-100 surfactant also play a crucial role for the aggregational phenomena of the amphiphiles mixed systems. Critical micelle concentration (cmc) of different mixtures was evaluated from the I-1/I-3 versus total amphiphile concentration plots. cmc value of pure drug and TX-100 as well as their mixtures in different ratio were also computed by dye solubilization method using UV-visible spectrophotometer. The different physicochemical parameters, such as micellar mole fraction (X-1(Rub)), activity coefficients (f(1)(m),f(2)(m)), micropolarity, micelle aggregation number (New), Stern-Volmer binding constants (K-sv) and dielectric constant (D-exp) have been evaluated for all solution mixture. Micelle aggregation numbers (N-agg) suggest that the involvement of TX-100 in the micelles was more than that of the AMT. Nuclear magnetic resonance (H-1 NMR) data of solution mixtures suggested that AMT and TX-100 interacts through hydrophobic interaction. (C) 2015 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.