Abstract
The study is associated with the effect of aspirin (Acetyl Salicylic Acid) on the microhardness of mineralized tissues of the offspring's teeth, in response to the ingestion of the drug during pregnancy. Aspirin is a widely used analgesic and antipyretic medicine, for symptomatic treatment. Misuse of this drug during pregnancy may instigate developmental defects in offspring. An experimental control study was designed, in which female rabbits were taken as representative mammalian models and treated with aspirin during pregnancy. Their offspring's teeth were used to assess the microhardness of dental tissues. The rabbits were alienated into two groups, treated and control, consisting of seven rabbits in each set (n = 7). Microhardness was evaluated in three types of the sample teeth. The total number of teeth examined were, 2 x 7 x 12 = 168 samples. Vicker's Hardness degree values were measured and recorded vis-a-vis (50 g for 15 s with 3 indentations per specimen on enamel and dentine separately). The range of hardness obtained was statistically analyzed and the Student's t-tests was applied, with the aid of SPSS version 20. The P-values for both enamel and dentine from maxillary incisors and molars were less than 0.05. The same trend was observed in the mandibular teeth. However, a teratogenicity of Acetyl Salicylic Acid was pragmatic in the recent in vivo studies. Based on the analysis, it was evident that the aspirin administration could produce negative effects leading to reduction in the microhardness of dental tissues of the offsprings. KEY WORDS: Dentition; Aspirin; Female rabbits; Teratogenic effect; Microhardness. El estudio asocia el efecto de la aspirina (acido acetil salicilico) sobre la microdureza de los tejidos mineralizados de los dientes de crias, en respuesta a la ingesta del farmaco durante la prenez. La aspirina es un analgesico y antipiretico ampliamente utilizado para el tratamiento sintomatico. El mal uso de esta droga durante la prenez puede inducir defectos en el desarrollo de las crias. Se diseno un estudio experimental de control, en el que se tomaron conejas como modelos de mamiferos representativos y fueron tratados con aspirina durante la prenez. Los dientes de sus crias fueron utilizados para evaluar la microdureza de los tejidos dentales. Los animales fueron distribuidos en dos grupos, tratados y control, con siete animales en cada grupo (n = 7). La microdureza se evaluo en tres tipos de dientes de la muestra. El numero total de dientes examinados fueron 168 (2 x 7 x 12). Se midieron y registraron valores del grado de dureza Vickers vis-a-vis (50 g por 15 s con 3 indentaciones por especimen sobre el esmalte y la dentina por separado). Se analizo estadisticamente la gama de dureza obtenida y se aplicaron pruebas t de Student con la ayuda del programa SPSS version 20. Los valores de p para el esmalte y la dentina de los incisivos maxilares y molares fueron menores a 0,05. Se observo la misma tendencia en los dientes mandibulares. Sin embargo, teratogenicidad producto del acido acetil salicilico se encontro en recientes estudios in vivo. De acuerdo al analisis de los resultados, se evidencio que la administracion de aspirina provoco efectos negativos que determinaron la reduccion de la microdureza de los tejidos dentales de las crias. PALABRAS CLAVE: Denticion; Aspirina; Conejos; Efecto teratogenico; Microdureza.