Abstract
Safe, minimally invasive, and cost-effective treatments are being sought to shortened orthodontic treatment time. Based on the well-known principle that orthodontic force triggers inflammatory pathways and osteoclast activity, we hypothesized that controlled micro-trauma in the form of micro-osteoperforations (MOPs) will amplify the expression of inflammatory markers that are normally expressed during orthodontic treatment and that this amplified response will accelerate both bone resorption and tooth movement. We tested our hypothesis in an animal model and in a human clinical trial. In adult rats, MOPs treatment significantly increased molar protraction with concomitant increase in inflammatory cytokine expression, osteoclastogenesis, and alveolar bone remodeling. Likewise, in human subjects, MOPs increased the rate of canine retraction concomitant with increased TNFα and IL-1β levels in gingival crevicular fluid. Moreover, MOPs treatment did not produce additional pain or discomfort in the patients tested. Our data supports our conclusion that MOPs offers a safe, minimally invasive, and easy mechanism to accelerate orthodontic tooth movement.