Microbial metabolism of artemisitene

Khaled Y Orabi; Ahmed M Galal; Abdel-Rahim S Ibrahim; Farouk S El-Feraly; Sherief I Khalifa; Hala N El-Sohly

doi:10.1016/S0031-9422(98)00770-5

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Microbial metabolism of artemisitene

Khaled Y Orabi, Ahmed M Galal, Abdel-Rahim S Ibrahim, Farouk S El-Feraly, Sherief I Khalifa and Hala N El-Sohly

Phytochemistry (Oxford), Vol.51(2), pp.257-261

01/05/1999

DOI: https://doi.org/10.1016/S0031-9422(98)00770-5

PMID: 10365449

Abstract

11- Epi-artemisinin

9β-Hydroxy-11- epi-artemisinin

9β-Hydroxydeoxy-11- epi-artemisinin

Artemisia annua

Artemisinin

Artemisitene

Asteraceae

Endoperoxide sesquiterpene

Microbial metabolism

Studies on the microbial transformation of the sesquiterpene endoperoxide artemisitene have revealed that artemisitene was metabolized by Aspergillus niger (NRRL 599) to yield 11- epi-artemisinin, 9β-hydroxydeoxy-11- epi-artemisinin and 9β-hydroxy-11- epi-artemisinnin. These metabolites were characterized on the basis of their spectral data.

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Details

Title: Microbial metabolism of artemisitene
Creators - without role: Khaled Y Orabi - King Saud University
Ahmed M Galal - King Saud University
Abdel-Rahim S Ibrahim - King Saud University
Farouk S El-Feraly - King Saud University
Sherief I Khalifa - Suez Canal University
Hala N El-Sohly - University of Mississippi
Publication Details: Phytochemistry (Oxford), Vol.51(2), pp.257-261
Publisher: Elsevier Ltd
Identifiers: 9952828508331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article