Abstract
A quantitative determination of the major compound, sarcophine, of ethyl acetate extracts in five species of the genus Sarcophyton determined by RP HPLC using ODS column. The HPLC analysis of S. glaucum, S. acutum, S. regulare, S. convolutum, S. ehrenbergi samples were collected from Hurghada in the Red Sea, as well as, microbial transformation of sarcophine was tested.