Microevolution of Mycobacterium tuberculosis in a tuberculosis patient

Sahal A M Al-Hajoj; Onno Akkerman; Ida Parwati; Saad al-Gamdi; Zeaur Rahim; Dick van Soolingen; Jakko van Ingen; Philip Supply; Adri G M van der Zanden

doi:10.1128/JCM.00556-10

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Microevolution of Mycobacterium tuberculosis in a tuberculosis patient

Journal article

Peer reviewed

Microevolution of Mycobacterium tuberculosis in a tuberculosis patient

Sahal A M Al-Hajoj, Onno Akkerman, Ida Parwati, Saad al-Gamdi, Zeaur Rahim, Dick van Soolingen, Jakko van Ingen, Philip Supply and Adri G M van der Zanden

Journal of clinical microbiology, Vol.48(10), pp.3813-6

01/10/2010

DOI: https://doi.org/10.1128/JCM.00556-10

PMCID: PMC2953119

PMID: 20686077

Abstract

Bacterial Typing Techniques

Cluster Analysis

DNA Fingerprinting

DNA Transposable Elements

DNA, Bacterial - genetics

Evolution, Molecular

Female

Genotype

Humans

Middle Aged

Mycobacterium tuberculosis - classification

Mycobacterium tuberculosis - genetics

Mycobacterium tuberculosis - isolation & purification

Netherlands

Tuberculosis - microbiology

Five Mycobacterium tuberculosis isolates were obtained from three body sites from a Dutch patient. The isolates displayed a single genotype by 24-locus MIRU-VNTR typing (except for a single locus not amplified from one isolate) but were differentiated by small variations in IS6110 fingerprints, spoligotypes, 6 hypervariable MIRU-VNTR loci, and/or DiversiLab profiles, revealing patterns of microevolution in a clonal infection.

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Title: Microevolution of Mycobacterium tuberculosis in a tuberculosis patient
Creators - without role: Sahal A M Al-Hajoj - Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. hajoj@kfshrc.edu.sa
Onno Akkerman - Medisch Spectrum Twente
Ida Parwati - Dr. Hasan Sadikin General Hospital
Saad al-Gamdi - Hera General Hospital
Zeaur Rahim - International Centre for Diarrhoeal Disease Research
Dick van Soolingen - National Institute for Public Health and the Environment
Jakko van Ingen - National Institute for Public Health and the Environment
Philip Supply - Center for Infection and Immunity of Lille
Adri G M van der Zanden - Laboratory for Medical Microbiology and Public Health, Enschede, Netherlands
Publication Details: Journal of clinical microbiology, Vol.48(10), pp.3813-6
Identifiers: 9931441908331
Academic Unit: Umm Al Qura University
Language: English
Resource Type: Journal article