Abstract
Novel pyrrolo [2,3-
] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the new derivatives were confirmed through spectral analysis. Compounds
and
were revealed to be the most effective hypolipidemic agents, with considerable hypocholesterolemic and hypotriglyceridemic effects. They appear to be promising candidates for creating new powerful derivatives with anti-atherosclerotic and hypolipidemic properties. As for antimicrobial activity, some of the tested compounds showed moderate activity against
: compound
revealed an MIC value of 50 μg/mL, compared to 25 μg/mL for ciprofloxacin. Compound
showed good antimicrobial activity against Staphylococcus aureus, comparable to ciprofloxacin, and roughly half the activity of ampicillin, according to MIC values. Compound
has an MIC approximately 25% of that of clotrimazole against Candida albicans. Compound
also showed the highest antioxidant activity with 59% inhibition of radical scavenging activity. Additionally, the cytotoxic activity of these new derivatives
-
was investigated and most of them showed good anticancer activity against the three tested cell lines.