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Microwave-Assisted Synthesis of Biotin Conjugates with Quinolone Antibiotics via Amino Acids
Journal article   Peer reviewed

Microwave-Assisted Synthesis of Biotin Conjugates with Quinolone Antibiotics via Amino Acids

Siva S. Panda, Roman N. Naumov, Abdullah M. Asiri and Alan R. Katritzky
Synthesis (Stuttgart), Vol.46(11), pp.1511-1517
02/06/2014
DOI: https://doi.org/10.1055/s-0033-1340978

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Benzotriazole-activated biotin was utilized as a versatile building block for the efficient and convenient synthesis of novel biotin conjugates with quinolone antibiotics via amino acid linkers under microwave irradiation. The products are obtained in yields of 70-91% with retention of chirality.

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