Abstract
A facile and effective method to access to the N-arylated-pyridopyrimidines starting from 4-thiol or 4-chloropyridopyrimidines under microwave irradiation, is reported. The products were obtained via two different strategies providing both exellent yields. The major advantages of this process are the short reaction time, and high productivity as well as being eco-friendly. Moreover, the obtained derivatives were assessed against different bacterial strains. Three derivatives were found to be highly effective against both studied bacterial strains.