Abstract
A facile, rapid and efficient microwave-assisted procedure for the synthesis of novel pyrazole, pyrimidine, and pyrazolo[1,5-a]pyrimidines linked to sulfonyl dibenzene moiety via the reaction of E-3-(N, N-dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one 3 with the appropriate amines described here. In general, microwave procedure as an eco-friendly energy source offers advantages such as a shorter reaction time, simple workup, reaction selectivity and improves an overall yield compared with conventional methods. The structures of all the compounds were confirmed by analytical and spectral data. [Ahmed A. El-Kateb, Naglaa M. Abd El-Rahman, Tamer S. Saleh, Ibrahim F. Zeid, Mohamed F. Mady. Microwave-Assisted Synthesis of Novel Pyrazole, Pyrimidine and Pyrazolo[1,5-a]pyrimidines Containing Aryl Sulfone Moiety. Life Science Journal 2012; 9(1):711-718]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 102