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Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
Journal article   Open access  Peer reviewed

Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

Sobhi M. Gomha, Thoraya A. Farghaly, Yahia Nasser Mabkhot, Mohie E. M. Zayed and Amany M. G. Mohamed
Molecules (Basel, Switzerland), Vol.22(3), p.346
23/02/2017
DOI: https://doi.org/10.3390/molecules22030346
PMCID: PMC6155381
PMID: 28241500

Abstract

Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary Life Sciences & Biomedicine Physical Sciences Science & Technology
In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/ sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used.
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https://doi.org/10.3390/molecules22030346View
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