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Microwave-assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)
Journal article   Peer reviewed

Microwave-assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)

Abdullah S. Al-Bogami and Ahmed E. M. Mekky
Journal of heterocyclic chemistry, Vol.53(5), pp.1554-1562
01/09/2016

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
We introduce efficient regioselective synthesis of a series of novel bis(pyrazoles) and bis(isoxazoles) via 1,3-dipolar cycloaddition reaction under microwave irradiation. Unequivocal structural assignment of the obtained regioisomers was determined utilizing H-1-C-13 HMBC NMR techniques as a valuable tool. A comparative study of the aforementioned reactions was carried out under conventional method as well as under microwave irradiation conditions.

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