Abstract
Because of the broad biological activities of phthalimide and maleimide derivatives, we synthesized a series of new phthalimide and maleimide derivatives for therapeutically active compounds by using the microwave-assisted synthesis method and evaluated them for in vitro antioxidant activity by using 1,1-diphenyl-2-picry lhydrazyl (DPPH) method. All the synthesized compounds were characterized by UV, H-1-NMR, and mass spectral analysis whereas TLC was performed to examine the completion of the reactions. The compound A(1) of the maleimide series and B-3 of the phthalimide series showed a higher percentage of practical yield, whereas compound A(3) of the maleimide series and B-4 of the phthalimide series exhibited higher antioxidant activity as compared to other compounds. These compounds were synthesized with the help of a microwave-assisted method and also exhibited considerable antioxidant activity. The compounds may also be further evaluated for other therapeutic benefits in animal models.