Abstract
In the current investigation, for the first time, silver nanoparticles (AgNPs) were synthesized using Annona squamosa peel extract as reducing and stabilizing agents via microwave irradiation assisted method. The nanoparticles had been characterized using UV-Vis, FTIR, XRD, and TEM techniques. The biosynthesized nanoparticles exhibited a broad peak at about 430 nm due to the surface plasmon resonance of the AgNPs. From the TEM images, the AgNPs are almost spherical, with an average size ranging from 18 to 35 nm. FT-IR analysis and phytochemical screening indicated that phenolic compounds and proteins of A. squamosa might have an essential role in AgNPs synthesis and stabilization. The antioxidant activity observed was almost comparable to the standard antioxidant agent (ascorbic acid). In vitro antidiabetic studies demonstrated the significant capability of AgNPs to inhibit the alpha-amylase in a dose-dependent manner. Thus, this green approach of AgNPs synthesis via microwave irradiated heating could be a quick, cost-effective, and environmentally friendly method, with the synthesized AgNPs proving to be a possible anti-diabetic therapeutic candidate.