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Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives
Journal article   Peer reviewed

Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

Sherif B. Abdel Ghani, Louise Weaver, H. Zidan Zidan, Hussein M. Ali, C. William Keevil and Richard C. D. Brown
Bioorganic & medicinal chemistry letters, Vol.18(2), pp.518-522
15/01/2008
DOI: https://doi.org/10.1016/j.bmcl.2007.11.081
PMID: 18068365

Abstract

Chemistry Chemistry, Medicinal Chemistry, Organic Life Sciences & Biomedicine Pharmacology & Pharmacy Physical Sciences Science & Technology
Eleven flavonoid derivatives were synthesised using a modified Baker-Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus. (c) 2007 Elsevier Ltd. All rights reserved.

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