Abstract
Schiff's bases of 1.2.4-triazole-3-thiol are synthesized by multistep reactions. Schiff bases are the condensation products of primary amines with carbonyl compounds. These compounds possess imine or azomethine (-C=N-) functional group in their structure and are considered as a synthon to design and develop the various lead molecules. They exhibit various biological activities such analgesic, anti-inflammatory, antimicrobial, anticancer, antitubercular, antioxidant. anthelmintic and anticonvulsant. etc. In the present study, benzohydrazide is used as the starting material. Benzohydrazide reacts with carbon disulphide and potassium hydroxide to produce potassium dithiocarbazinate. Potassium dithiocarbazinate undergoes cyclization in presence of hydrazine hydrate to yield 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol. Finally, Schiff's bases is synthesized by reaction of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol with substituted benzaldehydes under microwave irradiations for 5-10 min. Microwave irradiation method has several advantages as compared to conventional heating method in terms of uniform heating, shorter reaction time, less byproduct formation and environmental friendly. The structures of all synthesized compounds were characterized and confirmed by FT-1R, H-1 NMR and mass spectral studies with an objective to develop novel biologically active compounds. All the titled compounds were screened for their anthelmintic activity.