Abstract
An efficient, eco-friendly, simple and facile synthesis of a novel class of imidazolium, pyridinium and pyridazinium-based ionic liquids and/or salts is described under both conventional procedure and microwave irradiation. The newly synthesized ILs were well-characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. Their in vitro antibacterial against a panel of Gram-positive and Gram-negative bacteria was measured by determination of the inhibition zone (IZ), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) and the results revealed that ILs containing imidazolium cation are very effective antibacterial agents, especially, 1,2-dimethyl-3-(3-phenoxypropyl)-1H-imidazol-3-ium bromide8. A correlation of structure and activities relationship of these ILs with respect to Lipinski rule of Five, drug likeness, toxicity profiles and other physico-chemical properties of drugs are described and verified experimentally.
•Novel class of imidazolium, pyridinium and pyridazinium-based ionic liquids•An efficient and eco-friendly Microwave-assisted stynthesis•Bactericidal activity screened against gram positive and gram negative pathogens•A correlation of structure and activities relationship of these ILs with respect to Lipinski rule of Five