Abstract
We present a novel, facile and efficient methodology for the synthesis of pyrazoles and pyrazolo[3,4-d]pyridazines linked to diaryl sulfone moiety using synthetic talc as a solid base catalyst under microwave irradiation, via 1,3-dipolar cycloaddition reaction of the E-3-(dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one with different hydrazonyl halides. All synthesized compounds were evaluated for antibacterial and antifungal activities. The results showed that most of the synthesized compounds exhibited promising antimicrobial activities.